Title:
SULFAMIDE USP8 INHIBITOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/061051
Kind Code:
A1
Abstract:
Disclosed in the present application are a class of compounds containing a thiazole or thiadiazole structure and the use thereof, which belong to the technical field of medicine. According to the present application, the structure of a lead compound is optimized by means of pharmacophore splitting, recombination, etc., to obtain a series of USP8 inhibitors having a new skeleton and containing a thiazole or thiadiazole structure, enriching the structural diversity of USP8 inhibitors.
Inventors:
LI ZHIYU (CN)
BIAN JINLEI (CN)
TIAN YUCHENG (CN)
LIU KANG (CN)
LIU RUOYI (CN)
BIAN JINLEI (CN)
TIAN YUCHENG (CN)
LIU KANG (CN)
LIU RUOYI (CN)
Application Number:
PCT/CN2022/114208
Publication Date:
April 20, 2023
Filing Date:
August 23, 2022
Export Citation:
Assignee:
UNIV CHINA PHARMA (CN)
International Classes:
C07D417/12; A61K31/426; A61K31/427; A61K31/428; A61K31/433; A61K31/438; A61K31/4439; A61K31/454; A61K31/4545; A61K31/496; A61P5/00; A61P7/00; A61P7/06; A61P25/00; A61P25/16; A61P25/28; A61P35/00; A61P35/02; C07D277/46; C07D277/82; C07D285/135; C07D417/14; C07D471/10; C07D487/08
Domestic Patent References:
| WO2020223548A1 | 2020-11-05 | |||
| WO2021136405A1 | 2021-07-08 | |||
| WO2011087738A2 | 2011-07-21 |
Foreign References:
| CN113912595A | 2022-01-11 | |||
| CN103209980A | 2013-07-17 |
Other References:
SYED NIDA, ILYAS AMBER, IDREES FARHA, ZARINA, HASHIM ZEHRA: "Inhibition of USP2 Induces Apoptosis through Down Regulation of Fatty Acid Synthase and Cyclin D1 in Triple Negative Breast Cancer", CURRENT PROTEOMICS, BENTHAM SCIENCE PUBLISHERS,, GB, vol. 17, no. 5, 16 July 2020 (2020-07-16), GB , pages 425 - 432, XP093057067, ISSN: 1570-1646, DOI: 10.2174/1570164617666191008093522
DATABASE REGISTRY ANONYMOUS : "-Benzenesulfonamide, N-[2-[[4-(6-ethyl-2-benzothiazolyl)-1- piperazinyl]carbonyl]phenyl]-4-fluoro-(CA INDEX NAME) ", XP093057069, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "-Benzamide, 2-[[(4-chlorophenyl)sulfonyl]amino]-N-(5,6-dimethoxy-2- benzothiazolyl)-(CA INDEX NAME) ", XP093057071, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "-Benzamide, N-(4-methoxy-6-nitro-2-benzothiazolyl)-2-[[(4- methoxyphenyl)sulfonyl]amino]-(CA INDEX NAME)", XP093057072, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "-Benzamide, N-(4-bromo-2-benzothiazolyl)-2-[[(4- methoxyphenyl)sulfonyl]amino]-(CA INDEX NAME)", XP093057073, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "-2-Pyridinesulfonamide, N-[2-[[4-(6-bromo-2-benzothiazolyl)-1- piperazinyl]carbonyl]phenyl]-6-methyl-(CA INDEX NAME) ", XP093057076, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "-Benzenesulfonamide, N-[2-[[4-(6-ethyl-2-benzothiazolyl)-1- piperazinyl]carbonyl]phenyl]-4-fluoro-(CA INDEX NAME) ", XP093057069, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "-Benzamide, 2-[[(4-chlorophenyl)sulfonyl]amino]-N-(5,6-dimethoxy-2- benzothiazolyl)-(CA INDEX NAME) ", XP093057071, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "-Benzamide, N-(4-methoxy-6-nitro-2-benzothiazolyl)-2-[[(4- methoxyphenyl)sulfonyl]amino]-(CA INDEX NAME)", XP093057072, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "-Benzamide, N-(4-bromo-2-benzothiazolyl)-2-[[(4- methoxyphenyl)sulfonyl]amino]-(CA INDEX NAME)", XP093057073, retrieved from STN
DATABASE REGISTRY ANONYMOUS : "-2-Pyridinesulfonamide, N-[2-[[4-(6-bromo-2-benzothiazolyl)-1- piperazinyl]carbonyl]phenyl]-6-methyl-(CA INDEX NAME) ", XP093057076, retrieved from STN
Attorney, Agent or Firm:
NANJING JINGWEI PATENT & TRADEMARK AGENCY CO., LTD (CN)
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