Title:
SULFIDE COMPOUND PRODUCTION METHOD
Document Type and Number:
WIPO Patent Application WO/2018/097149
Kind Code:
A1
Abstract:
This sulfide compound production method involves a first step in which a sulfonic acid chloride of a specific structure is reacted with a saturated alcohol compound of a specific structure in the presence of a base to obtain a corresponding sulfonyl derivative, and a second step for reacting a 2-mercaptobenzothiazole derivative with said sulfonyl derivative to obtain a corresponding sulfide compound. With this production method, it is possible to synthesize, from a saturated alcohol compound, a corresponding sulfide compound in one pot at a realistic yield, without the use of phosphorus compounds such as triphenylphosphine.
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Inventors:
TSUCHIYA HIDEYOSHI (JP)
Application Number:
PCT/JP2017/041913
Publication Date:
May 31, 2018
Filing Date:
November 22, 2017
Export Citation:
Assignee:
TEIJIN PHARMA LTD (JP)
International Classes:
C07D277/74
Domestic Patent References:
| WO1998054153A1 | 1998-12-03 | |||
| WO2009133687A1 | 2009-11-05 |
Foreign References:
| JP2015231988A | 2015-12-24 | |||
| CN105777665A | 2016-07-20 | |||
| JP2011507878A | 2011-03-10 |
Other References:
BONINI, CARLO: "One-Pot Practical Preparation of Novel Propargylic Aryl and Heteroaryl", SYNLETT, no. 20, 28 November 2005 (2005-11-28), pages 3067 - 3070, XP055630993, DOI: 10.1055/s-2005-922750
JENNIFER A. LAFONTAINE, DAVID P. PROVENCAL, CRISTINA GARDELLI, JAMES W. LEAHY: "Enantioselective Total Synthesis of the Antitumor Macrolide Rhizoxin D", JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 11, 19 April 2003 (2003-04-19), pages 4215 - 4234, XP055630996, DOI: 10.1021/jo034011x
JENNIFER A. LAFONTAINE, DAVID P. PROVENCAL, CRISTINA GARDELLI, JAMES W. LEAHY: "Enantioselective Total Synthesis of the Antitumor Macrolide Rhizoxin D", JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 11, 19 April 2003 (2003-04-19), pages 4215 - 4234, XP055630996, DOI: 10.1021/jo034011x
Attorney, Agent or Firm:
TAMEYAMA Taro (JP)
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