Title:
SULFONAMIDE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2003/007931
Kind Code:
A1
Abstract:
Drugs for potentiating the effect of cancer therapy based on the function mechanism of injuring DNA which contain compounds represented by the general formula (I) or physiologically acceptable salts thereof as the active ingredient: (I) wherein R represents aryl−substituted alkyl, heteroaryl−substituted alkyl, cycloalkyl−substituted alkyl or cyclic hydrocarbyl (wherein the cyclic hydrocarbyl may be saturated, partly saturated or aromatic)&semi and Z represents hydrogen or C1−6 alkyl, provided that Z may be bonded to R to form a cyclic structure. These drugs potentiate the effect of cancer therapy and lessen the administration dose of anticancer agents and&sol or radiation dose, thereby relieving side effects accompanying cancer therapy.
Inventors:
MUTO SUSUMU (JP)
KOMUKAI MASAYUKI (JP)
ITAI AKIKO (JP)
KOMUKAI MASAYUKI (JP)
ITAI AKIKO (JP)
Application Number:
PCT/JP2002/005671
Publication Date:
January 30, 2003
Filing Date:
June 07, 2002
Export Citation:
Assignee:
INST MED MOLECULAR DESIGN INC (JP)
MUTO SUSUMU (JP)
KOMUKAI MASAYUKI (JP)
ITAI AKIKO (JP)
MUTO SUSUMU (JP)
KOMUKAI MASAYUKI (JP)
ITAI AKIKO (JP)
International Classes:
A61K31/18; A61K31/341; A61K31/36; A61K31/4035; A61K31/407; A61K31/4184; A61K31/4402; A61K31/472; A61K31/675; A61K31/704; A61K33/24; A61K45/06; A61P35/00; A61P43/00; C07C311/39; C07C311/40; C07C311/41; C07C311/42; C07C311/43; C07C311/44; C07C317/32; C07D209/44; C07D213/42; C07D215/58; C07D217/08; C07D235/14; C07D307/52; C07D317/58; C07D235/10; (IPC1-7): A61K31/18; A61K31/341; A61K31/36; A61K31/4035; A61K31/407; A61K31/4184; A61K31/4402; A61K31/472; A61K31/675; A61K31/704; A61K33/24; A61K38/00; A61P35/00; A61P43/00; C07C311/39; C07C311/40; C07C311/41; C07C311/42; C07C311/43; C07C311/44; C07D209/44; C07D213/42; C07D217/08; C07D235/14; C07D307/52; C07D317/58
Domestic Patent References:
| WO2000032577A2 | 2000-06-08 |
Foreign References:
| EP0950656A1 | 1999-10-20 | |||
| EP0366061A1 | 1990-05-02 | |||
| EP0007206A1 | 1980-01-23 | |||
| EP0305008A2 | 1989-03-01 | |||
| JPS60126219A | 1985-07-05 |
Other References:
See also references of EP 1402890A4
Attorney, Agent or Firm:
SIKS & CO. (Kyobashi-Nisshoku Bldg. 8-7, Kyobashi 1-chom, Chuo-ku Tokyo, JP)
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