Title:
SULFONAMIDE AND SULFONIC ESTER DERIVATIVES EACH HAVING TRICYCLIC HETERO RING
Document Type and Number:
WIPO Patent Application WO/1995/003279
Kind Code:
A1
Abstract:
Novel antitumor sulfonamide and sulfonic ester derivatives each having a tricyclic hetero ring, represented by general formula (I), and a process for producing the same, wherein G represents a 5- or 6-membered aromatic ring; L represents O or NR1, wherein R1 represents hydrogen or lower alkyl; and M represents a tricyclic structure selected from the members (a), (b), (c), (d), (e), (f), wherein rings A and B represent each a 5- or 6-membered unsaturated ring; X represents NR2 (wherein R2 represents hydrogen or lower alkyl) or NHCO; Y represents O, S(O)n, CR3R4, CO, NR5, CHR6CHR7, CR8=CR9, NR10CO, N=CR11, OCHR12, S(O)nCHR13 or NR14CHR15; and Z represents N or CR16, wherein n represents 0, 1 or 2; R3-R13, R15 and R16 represent each hydrogen or lower alkyl; and R14 represents hydrogen, lower alkyl or lower acyl.
More Like This:
Inventors:
YOSHINO HIROSHI (JP)
UEDA NORIHIRO (JP)
NIIJIMA JUN (JP)
HANEDA TORU (JP)
KOTAKE YOSHIHIKO (JP)
YOSHIMATSU KENTARO (JP)
WATANABE TATSUO (JP)
NAGASU TAKESHI (JP)
TSUKAHARA NAOKO (JP)
KOYANAGI NOZOMU (JP)
KITO KYOSUKE (JP)
UEDA NORIHIRO (JP)
NIIJIMA JUN (JP)
HANEDA TORU (JP)
KOTAKE YOSHIHIKO (JP)
YOSHIMATSU KENTARO (JP)
WATANABE TATSUO (JP)
NAGASU TAKESHI (JP)
TSUKAHARA NAOKO (JP)
KOYANAGI NOZOMU (JP)
KITO KYOSUKE (JP)
Application Number:
PCT/JP1994/001231
Publication Date:
February 02, 1995
Filing Date:
July 26, 1994
Export Citation:
Assignee:
EISAI CO LTD (JP)
YOSHINO HIROSHI (JP)
UEDA NORIHIRO (JP)
NIIJIMA JUN (JP)
HANEDA TORU (JP)
KOTAKE YOSHIHIKO (JP)
YOSHIMATSU KENTARO (JP)
WATANABE TATSUO (JP)
NAGASU TAKESHI (JP)
TSUKAHARA NAOKO (JP)
KOYANAGI NOZOMU (JP)
KITO KYOSUKE (JP)
YOSHINO HIROSHI (JP)
UEDA NORIHIRO (JP)
NIIJIMA JUN (JP)
HANEDA TORU (JP)
KOTAKE YOSHIHIKO (JP)
YOSHIMATSU KENTARO (JP)
WATANABE TATSUO (JP)
NAGASU TAKESHI (JP)
TSUKAHARA NAOKO (JP)
KOYANAGI NOZOMU (JP)
KITO KYOSUKE (JP)
International Classes:
C07C211/55; C07C229/58; C07C311/29; C07D209/88; C07D219/04; C07D219/06; C07D219/08; C07D221/12; C07D223/22; C07D243/38; C07D265/38; C07D267/18; C07D267/20; C07D279/20; C07D281/14; C07D413/12; C07D498/04; C07D513/04; C07F7/18; (IPC1-7): C07D209/88; C07D219/08; C07D221/21; C07D223/22; C07D241/46; C07D243/38; C07D253/06; C07D265/38; C07D267/18; C07D267/20; C07D279/14; C07D279/20; C07D281/08; C07D285/20; C07D285/36; C07D413/12; C07D498/04; C07D513/04; A61K31/40; A61K31/47; A61K31/495; A61K31/535; A61K31/54; A61K31/55
Foreign References:
| JPS433093B1 | ||||
| JPS62426A | 1987-01-06 | |||
| JPH0539256A | 1993-02-19 |
Other References:
Research Annual Report of Nagoya University, Pharmaceutical Department No. 18 (1970), HIDEAKI SHIRAI et al.: pages 77-78, & CHEMICAL ABSTRACTS, Vol. 75, Abstract No. 98514.
Pakistan J. Sci. Ind. Res., Vol. 26, No. 2, April 1983, SALIMUZZAMAN SIDDIQUI et al.: pp. 53-8.
Pakistan J. Sci. Ind. Res., Vol. 28, No. 4, August 1985, SALIMUZZAMAN SIDDIQUI et al.: pp. 221-4.
Pakistan J. Sci. Ind. Res., Vol. 25, No. 5, October 1982, SALIMUZZAMAN SIDDIQUI et al.: pp. 147-52.
See also references of EP 0679641A4
Pakistan J. Sci. Ind. Res., Vol. 26, No. 2, April 1983, SALIMUZZAMAN SIDDIQUI et al.: pp. 53-8.
Pakistan J. Sci. Ind. Res., Vol. 28, No. 4, August 1985, SALIMUZZAMAN SIDDIQUI et al.: pp. 221-4.
Pakistan J. Sci. Ind. Res., Vol. 25, No. 5, October 1982, SALIMUZZAMAN SIDDIQUI et al.: pp. 147-52.
See also references of EP 0679641A4
Download PDF: