Title:
SULFONATED HYALURONIC ACID COMPOUND, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/065439
Kind Code:
A1
Abstract:
The present invention relates to the cross-technical fields of medicine, material chemistry, glycobiology and the like, in particular to a sulfonated hyaluronic acid compound, a preparation method therefor and an application thereof. The structural formula of the sulfonated hyaluronic acid compound is shown as in formula (I), wherein R is alkali metal cation or hydrogen, R1, R2, R3, and R4 are respectively independently selected from hydrogen or sulfonate ions and R1, R2, R3, and R4 cannot be hydrogen at the same time, 10
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Inventors:
WANG CHUNMING (CN)
CHEN JIAXI (CN)
XIE DAPING (CN)
ZHANG ZHE (CN)
CHEN JIAXI (CN)
XIE DAPING (CN)
ZHANG ZHE (CN)
Application Number:
PCT/CN2021/130827
Publication Date:
April 27, 2023
Filing Date:
November 16, 2021
Export Citation:
Assignee:
UNIV MACAU (CN)
International Classes:
C08B37/08; A61K31/728; A61P1/16; A61P1/18; A61P9/00; A61P11/00; A61P13/12
Domestic Patent References:
| WO2009013162A1 | 2009-01-29 |
Foreign References:
| CN111050778A | 2020-04-21 | |||
| US20130209531A1 | 2013-08-15 | |||
| JP2001097997A | 2001-04-10 | |||
| KR20200055645A | 2020-05-21 | |||
| US20170360789A1 | 2017-12-21 | |||
| US20170202982A1 | 2017-07-20 | |||
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| US20030060448A1 | 2003-03-27 | |||
| CN102427808A | 2012-04-25 | |||
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Other References:
BHATTACHARYA DEEP S., SVECHKAREV DENIS, BAPAT AISHWARYA, PATIL PRATHAMESH, HOLLINGSWORTH MICHAEL A., MOHS AARON M.: "Sulfation Modulates the Targeting Properties of Hyaluronic Acid to P-Selectin and CD44", ACS BIOMATERIALS SCIENCE & ENGINEERING, vol. 6, no. 6, 8 June 2020 (2020-06-08), pages 3585 - 3598, XP093058632, ISSN: 2373-9878, DOI: 10.1021/acsbiomaterials.0c00115
BHATTACHARYA DEEP S.: "Engineering Hyaluronic Acid for Biomedical Applications", THESES & DISSERTATIONS, UNIVERSITY OF NEBRASKA MEDICAL CENTER, 1 November 2019 (2019-11-01), University of Nebraska Medical Center, XP093058635, Retrieved from the Internet [retrieved on 20230628]
KOEHLER LINDA, SAMSONOV SERGEY, ROTHER SANDRA, VOGEL SARAH, KöHLING SEBASTIAN, MOELLER STEPHANIE, SCHNABELRAUCH MATTHIAS, RAD: "Sulfated Hyaluronan Derivatives Modulate TGF-β1:Receptor Complex Formation: Possible Consequences for TGF-β1 Signaling", SCIENTIFIC REPORTS, vol. 7, no. 1, 1 December 2017 (2017-12-01), XP055780190, DOI: 10.1038/s41598-017-01264-8
BHATTACHARYA DEEP S.: "Engineering Hyaluronic Acid for Biomedical Applications", THESES & DISSERTATIONS, UNIVERSITY OF NEBRASKA MEDICAL CENTER, 1 November 2019 (2019-11-01), University of Nebraska Medical Center, XP093058635, Retrieved from the Internet
KOEHLER LINDA, SAMSONOV SERGEY, ROTHER SANDRA, VOGEL SARAH, KöHLING SEBASTIAN, MOELLER STEPHANIE, SCHNABELRAUCH MATTHIAS, RAD: "Sulfated Hyaluronan Derivatives Modulate TGF-β1:Receptor Complex Formation: Possible Consequences for TGF-β1 Signaling", SCIENTIFIC REPORTS, vol. 7, no. 1, 1 December 2017 (2017-12-01), XP055780190, DOI: 10.1038/s41598-017-01264-8
Attorney, Agent or Firm:
FOUNDIN INTELLECTUAL PROPERTY (CN)
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