Title:
SULFONIC ACIDS, THEIR DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
Document Type and Number:
WIPO Patent Application WO2004080951
Kind Code:
A3
Abstract:
Selected sulfonic acids, their derivatives and pharmaceutical compositions containing such compounds are useful in inhibiting the chernotactic activation of neutrophils (PMN leukocytes) induced by the interaction of Interleukin-8 (IL-8) with CXCRI and CXCR2 membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. Notably, the selected sulfonic acids and their derivativas are devoid of cyclo-oxygenase inhibition activity and are particularly useful in the treatment of neutrofil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.
Inventors:
ALLEGRETTI MARCELLO (IT)
ARAMINI ANDREA (IT)
CESTA MARIA CANDIDA (IT)
BERTINI RICCARDO (IT)
BIZZARRI CINZIA (IT)
COLOTTA FRANCESCO (IT)
ARAMINI ANDREA (IT)
CESTA MARIA CANDIDA (IT)
BERTINI RICCARDO (IT)
BIZZARRI CINZIA (IT)
COLOTTA FRANCESCO (IT)
Application Number:
PCT/EP2004/050293
Publication Date:
November 04, 2004
Filing Date:
March 11, 2004
Export Citation:
Assignee:
DOMPE SPA (IT)
ALLEGRETTI MARCELLO (IT)
ARAMINI ANDREA (IT)
CESTA MARIA CANDIDA (IT)
BERTINI RICCARDO (IT)
BIZZARRI CINZIA (IT)
COLOTTA FRANCESCO (IT)
ALLEGRETTI MARCELLO (IT)
ARAMINI ANDREA (IT)
CESTA MARIA CANDIDA (IT)
BERTINI RICCARDO (IT)
BIZZARRI CINZIA (IT)
COLOTTA FRANCESCO (IT)
International Classes:
A61K31/10; A61K31/18; A61P29/00; C07C309/24; C07C309/29; C07C309/65; C07C309/73; C07C311/08; C07C311/13; C07C311/16; C07C311/21; C07C311/27; C07C311/35; C07C311/51; C07D207/263; C07D207/27; C07D207/333; C07D207/26; C07D207/32; (IPC1-7): C07C309/24; C07C309/29; C07C311/16; C07C311/21; C07D207/263; C07D207/333; A61K31/18; A61K31/10; A61P29/00
Domestic Patent References:
| WO2000024710A1 | 2000-05-04 |
Other References:
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002254775, retrieved from XFIRE Database accession no. brn 2110387
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002254783, retrieved from XFIRE Database accession no. 4742262
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002254784, retrieved from XFIRE Database accession no. 8977246
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002254786, retrieved from XFIRE Database accession no. 2649523
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002254787, retrieved from XFIRE Database accession no. 2652292
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002254783, retrieved from XFIRE Database accession no. 4742262
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002254784, retrieved from XFIRE Database accession no. 8977246
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002254786, retrieved from XFIRE Database accession no. 2649523
DATABASE CROSSFIRE BEILSTEIN [online] Beilstein Institut zur Förderung der Chemischen Wissenschaften, Frankfurt am Main, DE; XP002254787, retrieved from XFIRE Database accession no. 2652292
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