Title:
SULPHUR-CONTAINING AMPHIPHILIC AGENTS FOR THE TRANSFER OF BIOLOGICALLY ACTIVE MOLECULES INTO CELLS
Document Type and Number:
WIPO Patent Application WO2002051800
Kind Code:
A3
Abstract:
The invention relates to amphiphilic, cationic, sulpho-substituted phosphatidylethanolamine analogues of formula (I), where X = -S-, -S(O)- or -S(O)2-and salts thereof, which can complex biopolymers such as DNA, RNA, oligonucleotides, ribozymes, proteins and peptides and introduce the above into eukaryotic cells. Particularly suitable are compounds derived from 1,2-dioleoyl-3-sn-phosphatidylethanolamine (DOPE) and in which the phosphate ester group of DOPE is replaced by an isosteric group CH2-SO-CH2 or CH2S(O)2-CH2. Said compounds are particularly suitable for application in gene therapy and also for diagnostic purposes as a result of the property thereof of forming aggregates with biologically active molecules such as DNA or RNA for example.
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Inventors:
KEIL OLIVER (DE)
Application Number:
PCT/DE2001/004843
Publication Date:
August 15, 2002
Filing Date:
December 21, 2001
Export Citation:
Assignee:
G O T THERAPEUTICS GMBH (DE)
KEIL OLIVER (DE)
KEIL OLIVER (DE)
International Classes:
A61K9/127; A61K47/48; C07C317/28; C12N15/88; (IPC1-7): C07C317/28; A61K47/48
Domestic Patent References:
| WO1991016024A1 | 1991-10-31 |
Foreign References:
| EP0747351A2 | 1996-12-11 |
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