SYNTHESIS OF BETA-LAPACHONE AND ITS INTERMEDIATES

Title:

SYNTHESIS OF BETA-LAPACHONE AND ITS INTERMEDIATES

Document Type and Number:

WIPO Patent Application WO2002059103

Kind Code:

A9

Abstract:

A novel process for synthesizing beta -lapachone (beta-lapachone), an agent that has demonstrated significant antineoplastic activity against human cancer lines. The process comprises the conversion of starting material, 2-hydroxy-1,4-naphothoquinone into beta -lapachone intermediate, lapachol. The lapachol is then converted to beta -lapachone by treatment with sulfuric acid and purified by recrystallization from ethanol. This novel process is extremely simple and provides beta -lapachone in excellent quality and high yield.

Inventors:

JIANG ZHIWEI (US)
HOGELAND JANE (US)

Application Number:

PCT/US2002/002359

Publication Date:

January 03, 2003

Filing Date:

January 23, 2002

Export Citation:

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Assignee:

CYCLIS PHARMACEUTICALS INC (US)
JIANG ZHIWEI (US)
HOGELAND JANE (US)

International Classes:

C07B61/00; C07D311/92; C07D311/78; (IPC1-7): C07D311/72

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