Title:
SYNTHETIC CHEMOKINES LABELED AT SELECTED POSITIONS
Document Type and Number:
WIPO Patent Application WO2004026893
Kind Code:
A3
Abstract:
Labeled synthetic chemokine molecules are provided which are characterized by improved biological activity and methods for their production and use in detection of chemokine receptors
Inventors:
DEMOTZ STEPHANE (CH)
MOULON CORINNE (CH)
STRONG ANDREW (CH)
VIZZAVONA JEAN (FR)
COUSIN PASCAL (CH)
REYMOND CHRISTOPHE (CH)
ROGGERO MARIO (CH)
MOULON CORINNE (CH)
STRONG ANDREW (CH)
VIZZAVONA JEAN (FR)
COUSIN PASCAL (CH)
REYMOND CHRISTOPHE (CH)
ROGGERO MARIO (CH)
Application Number:
PCT/EP2003/010698
Publication Date:
May 27, 2004
Filing Date:
September 23, 2003
Export Citation:
Assignee:
RMF DICTAGENE SA (CH)
DEMOTZ STEPHANE (CH)
MOULON CORINNE (CH)
STRONG ANDREW (CH)
VIZZAVONA JEAN (FR)
COUSIN PASCAL (CH)
REYMOND CHRISTOPHE (CH)
ROGGERO MARIO (CH)
DEMOTZ STEPHANE (CH)
MOULON CORINNE (CH)
STRONG ANDREW (CH)
VIZZAVONA JEAN (FR)
COUSIN PASCAL (CH)
REYMOND CHRISTOPHE (CH)
ROGGERO MARIO (CH)
International Classes:
C07K1/13; C07K14/52; (IPC1-7): C07K1/13; C07K14/52
Domestic Patent References:
| WO2000012554A1 | 2000-03-09 |
Other References:
THIERRY ANNE-CHRISTINE ET AL: "Long synthetic peptides as biologically active proteins: The example of the chemokines", BIOLOGICALS, vol. 29, no. 3-4, September 2001 (2001-09-01), pages 259 - 263, XP002274174, ISSN: 1045-1056
VITA C ET AL: "Synthesis and characterization of biologically functional biotinylated RANTES", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER, AMSTERDAM, NL, vol. 266, no. 1-2, 1 August 2002 (2002-08-01), pages 53 - 65, XP004372271, ISSN: 0022-1759
OFFORD R E ET AL: "Synthesis and evaluation of fluorescent chemokines labeled at the amino terminal.", METHODS IN ENZYMOLOGY. UNITED STATES 1997, vol. 287, 1997, pages 348 - 369, XP002274175, ISSN: 0076-6879
PEURALAHTI JARI ET AL: "Synthesis of nonluminescent lanthanide(III) chelates tethered to an aminooxy group and their applicability to biomolecule derivatization", BIOCONJUGATE CHEMISTRY, vol. 13, no. 4, July 2002 (2002-07-01), pages 876 - 880, XP002274176, ISSN: 1043-1802
THIERRY ANNE-CHRISTINE ET AL: "Biotinylated synthetic chemokines: their use for the development of nonradioactive whole-cell binding assays.", JOURNAL OF BIOMOLECULAR SCREENING: THE OFFICIAL JOURNAL OF THE SOCIETY FOR BIOMOLECULAR SCREENING. UNITED STATES JUN 2003, vol. 8, no. 3, June 2003 (2003-06-01), pages 316 - 323, XP009027971, ISSN: 1087-0571
VITA C ET AL: "Synthesis and characterization of biologically functional biotinylated RANTES", JOURNAL OF IMMUNOLOGICAL METHODS, ELSEVIER, AMSTERDAM, NL, vol. 266, no. 1-2, 1 August 2002 (2002-08-01), pages 53 - 65, XP004372271, ISSN: 0022-1759
OFFORD R E ET AL: "Synthesis and evaluation of fluorescent chemokines labeled at the amino terminal.", METHODS IN ENZYMOLOGY. UNITED STATES 1997, vol. 287, 1997, pages 348 - 369, XP002274175, ISSN: 0076-6879
PEURALAHTI JARI ET AL: "Synthesis of nonluminescent lanthanide(III) chelates tethered to an aminooxy group and their applicability to biomolecule derivatization", BIOCONJUGATE CHEMISTRY, vol. 13, no. 4, July 2002 (2002-07-01), pages 876 - 880, XP002274176, ISSN: 1043-1802
THIERRY ANNE-CHRISTINE ET AL: "Biotinylated synthetic chemokines: their use for the development of nonradioactive whole-cell binding assays.", JOURNAL OF BIOMOLECULAR SCREENING: THE OFFICIAL JOURNAL OF THE SOCIETY FOR BIOMOLECULAR SCREENING. UNITED STATES JUN 2003, vol. 8, no. 3, June 2003 (2003-06-01), pages 316 - 323, XP009027971, ISSN: 1087-0571
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