SYSTEMS FOR CELL PROGRAMMING AND METHODS THEREOF

Title:

SYSTEMS FOR CELL PROGRAMMING AND METHODS THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/158750

Kind Code:

A3

Abstract:

Provided herein are systems of modulating gene expression, methods of use thereof, and cells engineered thereof for the purpose of differentiating cells, for example immune cells.

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Inventors:

CLARKE RYAN (US)
MERRILL BRADLEY J (US)
MACDOUGALL MATTHEW (US)
BALANIS NIKOLAS GEORGE KOUTIS (US)
DE POOTER RENEE (US)
HARDING CASPIAN (US)
MANCINELLI GEORGINA (US)

Application Number:

PCT/US2023/013240

Publication Date:

November 16, 2023

Filing Date:

February 16, 2023

Export Citation:

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Assignee:

SYNTAX BIO INC (US)

International Classes:

C12N15/63; C12N9/22; C12N15/113; G06N3/12

Foreign References:

US20210340566A1	2021-11-04
US20210005279A1	2021-01-07

Other References:

FARZADFARD FAHIM; GHARAEI NAVA; HIGASHIKUNI YASUTOMI; JUNG GIYOUNG; CAO JICONG; LU TIMOTHY K.: "Single-Nucleotide-Resolution Computing and Memory in Living Cells", MOLECULAR CELL, ELSEVIER, AMSTERDAM, NL, vol. 75, no. 4, 22 August 2019 (2019-08-22), AMSTERDAM, NL, pages 769, XP085777605, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.07.011
KIM ET AL.: "A CRISPR/Cas9-based central processing unit to program complex logic computation in human cells", PROC NAIL ACAD SCI USA, vol. 116, 9 April 2019 (2019-04-09), pages 7214 - 7219, XP055736181, DOI: 10.1073/pnas.1821740116

Attorney, Agent or Firm:

COHEN, Sarah M. (US)

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