TABLETED MEDICINAL COMPOSITION COMPRISING NALFURAFINE

Title:

TABLETED MEDICINAL COMPOSITION COMPRISING NALFURAFINE

Document Type and Number:

WIPO Patent Application WO/2018/181920

Kind Code:

A1

Abstract:

The purpose of the present invention is to provide a tableted medicinal composition comprising nalfurafine or a pharmacologically acceptable acid addition salt thereof, said composition having a high moldability and excellent quality control properties of analogous substances. Provided is a tableted medicinal composition comprising nalfurafine or a pharmacologically acceptable acid addition salt thereof, a binder component and a carrier, wherein: the content of nalfurafine or a pharmacologically acceptable acid addition salt thereof is 0.1-10 μg; and the weight of the binder component is 100,000-2,000,000 wt% relative to the weight of nalfurafine or a pharmacologically acceptable acid addition salt thereof and 5-20 wt% relative to the total weight of the obtained medicinal composition, or 20,000-500,000 wt% and 1-5 wt% relative to the total weight of the obtained medicinal composition.

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Inventors:

MINAKAMI SATOSHI (JP)
TAKAKI SUGURU (JP)
OHTA KOTOE (JP)
HORIUCHI YASUHIDE (JP)

Application Number:

PCT/JP2018/013684

Publication Date:

October 04, 2018

Filing Date:

March 30, 2018

Export Citation:

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Assignee:

TORAY INDUSTRIES (JP)

International Classes:

A61K31/485; A61K9/20; A61K47/10; A61K47/26; A61K47/36; A61K47/38; A61P17/04

Domestic Patent References:

WO2010113841A1	2010-10-07
WO1999002158A1	1999-01-21
WO2008133330A1	2008-11-06
WO2010047381A1	2010-04-29
WO1995020380A1	1995-08-03

Other References:

PARASRAMPURIA, J. ET AL.: "Quantitation of Famotidine in Pharmaceutical Dosage Forms Using High- Performance Liquid Chromatography", DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, vol. 15, no. 12, 1989, pages 1989 - 1997, XP009516968, DOI: 10.3109/03639048909052514
"Japanese Pharmaceutical Excipients Directory", 18 February 2016, JAPAN PHARMACEUTICAL EXCIPIENTS COUNCIL, YAKUJI NIPPO LTD.
See also references of EP 3603643A4

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