Title:
TAK1 INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2002/048135
Kind Code:
A1
Abstract:
TAK1 inhibitors or TAK1 activation inhibitors containing as the active ingredient zearalenones having hydroxyl groups at both of the 8- and 9-positions; a method of inhibiting TAK1 or a method of inhibiting the activation of TAK1 by using as the active ingredient zearalenones having hydroxyl groups at both of the 8- and 9-positions; utilization of zearalenones having hydroxyl groups at both of the 8- and 9-positions for producing TAK1 inhibitors or TAK1 activation inhibitors; and kits for inhibiting TAK1 or kits for inhibiting the activation of TAK1 containing zearalenones having hydroxyl groups at both of the 8- and 9-position and a manual.
Inventors:
TSUCHIYA MASAYUKI (JP)
OHTOMO TOSHIHIKO (JP)
ONO KOICHIRO (JP)
MATSUMOTO MASAHIKO (JP)
ITO TATSUYA (JP)
OHTOMO TOSHIHIKO (JP)
ONO KOICHIRO (JP)
MATSUMOTO MASAHIKO (JP)
ITO TATSUYA (JP)
Application Number:
PCT/JP2001/010927
Publication Date:
June 20, 2002
Filing Date:
December 13, 2001
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
TSUCHIYA MASAYUKI (JP)
OHTOMO TOSHIHIKO (JP)
ONO KOICHIRO (JP)
MATSUMOTO MASAHIKO (JP)
ITO TATSUYA (JP)
TSUCHIYA MASAYUKI (JP)
OHTOMO TOSHIHIKO (JP)
ONO KOICHIRO (JP)
MATSUMOTO MASAHIKO (JP)
ITO TATSUYA (JP)
International Classes:
A61K31/335; A61K31/336; A61K31/365; A61P43/00; C07D313/00; C07D493/04; (IPC1-7): C07D313/00; A61K31/365; A61P43/00; C07D493/04
Foreign References:
| EP0606044A1 | 1994-07-13 |
Other References:
MATSUOKA MASATO ET AL.: "Inhibition of HgC12-induced mitogen-activated protein kinase by LL-Z1640 in CCRF-CEM cells", EUR. J. PHARMACOL., vol. 409, 2000, pages 155 - 158, XP002908835
RAWLINS PHILIP ET AL.: "Inhibition of endotoxin-induced TNF-alpha production in macrophages by 5Z-7-oxo-zeaenol and other fungal resorcyclic acid lactones", INTERNATINAL JOURNAL OF IMMUNOPHARMACOLOGY, vol. 21, 1999, pages 799 - 814, XP002908837
YAMAGUCHI KYOKO ET AL.: "Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction", SCIENCE, vol. 270, 1995, pages 2008 - 2011, XP002103399
RAWLINS PHILIP ET AL.: "Inhibition of endotoxin-induced TNF-alpha production in macrophages by 5Z-7-oxo-zeaenol and other fungal resorcyclic acid lactones", INTERNATINAL JOURNAL OF IMMUNOPHARMACOLOGY, vol. 21, 1999, pages 799 - 814, XP002908837
YAMAGUCHI KYOKO ET AL.: "Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction", SCIENCE, vol. 270, 1995, pages 2008 - 2011, XP002103399
Attorney, Agent or Firm:
Shamoto, Ichio (New Ohtemachi Bldg. 2-1 Ohtemachi 2-chome Chiyoda-ku, Tokyo, JP)
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