Title:
TARGET MARKER GP73 FOR DETECTING STEATOHEPATITIS AND DETECTION APPLICATION METHOD
Document Type and Number:
WIPO Patent Application WO/2018/227643
Kind Code:
A1
Abstract:
A novel serological target marker GP73 used for diagnosing and identifying a simple fatty change and steatohepatitis in crowds with fatty liver and a detection application method thereof. The serological target marker GP73 and the application thereof can replace golden standard liver puncture to identify and diagnose the simple fatty change and steatohepatitis in crowds with fatty liver, reduce the detection pain of a patient, and have an extremely high clinical application value in clinically identifying and diagnosing the simple fatty change and steatohepatitis in the crowds with fatty liver and assisting the treatment of the simple fatty change and steatohepatitis.
Inventors:
WEI HONGSHAN (CN)
LI BOAN (CN)
LIN CHANGQING (CN)
QIAO YONG (CN)
LI BOAN (CN)
LIN CHANGQING (CN)
QIAO YONG (CN)
Application Number:
PCT/CN2017/088945
Publication Date:
December 20, 2018
Filing Date:
June 19, 2017
Export Citation:
Assignee:
BEIJING DITAN HOSPITAL CAPITAL MEDICAL UNIVERSTY (CN)
BEIJING HOTGEN BIOTECH CO LTD (CN)
BEIJING HOTGEN BIOTECH CO LTD (CN)
International Classes:
G01N33/576
Foreign References:
| EP3056905A1 | 2016-08-17 | |||
| CN106290872A | 2017-01-04 | |||
| CN105189549A | 2015-12-23 | |||
| CN101735319A | 2010-06-16 | |||
| CN101407544A | 2009-04-15 | |||
| CN104215761A | 2014-12-17 | |||
| US4816567A | 1989-03-28 | |||
| CN101735319A | 2010-06-16 |
Other References:
WEI, HONGSHAN ET AL.: "GP73 (Non official translation: Effect of Hepatocyte Steatosis on Serum Glycoprotein GP73 Level", CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY, vol. 27, no. 4, 31 August 2013 (2013-08-31), pages 244 - 246, XP009518304, DOI: 10.3760/cma.j.issn.1003-9279.2013.04.002
FENG, ZHIGANG ET AL.: "GP73 (Diagnostic Value GP73 in Alcoholic Liver Disease", INTERNATIONAL JOURNAL OF LABORATORY MEDICINE, vol. 36, no. 15, 31 August 2015 (2015-08-31), pages 2214 - 2215, XP009518306
XU, WENFANG ET AL.: "Non-official translation: Expression Level of Serum GP73 in Patients with Liver Diseases", JOURNAL OF RADIO IMMUNOLOGY, vol. 25, no. 2, 31 December 2012 (2012-12-31), pages 190 - 193, XP009518302
KOHLER ET AL., NATURE, vol. 256, 1975, pages 495
CLACKSON ET AL., NATURE, vol. 352, 1991, pages 624 - 628
MARKS ET AL., J. MOL. BIOL., vol. 222, 1991, pages 581 - 597
See also references of EP 3640644A4
FENG, ZHIGANG ET AL.: "GP73 (Diagnostic Value GP73 in Alcoholic Liver Disease", INTERNATIONAL JOURNAL OF LABORATORY MEDICINE, vol. 36, no. 15, 31 August 2015 (2015-08-31), pages 2214 - 2215, XP009518306
XU, WENFANG ET AL.: "Non-official translation: Expression Level of Serum GP73 in Patients with Liver Diseases", JOURNAL OF RADIO IMMUNOLOGY, vol. 25, no. 2, 31 December 2012 (2012-12-31), pages 190 - 193, XP009518302
KOHLER ET AL., NATURE, vol. 256, 1975, pages 495
CLACKSON ET AL., NATURE, vol. 352, 1991, pages 624 - 628
MARKS ET AL., J. MOL. BIOL., vol. 222, 1991, pages 581 - 597
See also references of EP 3640644A4
Attorney, Agent or Firm:
BEIJING TECHSTONE INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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