Title:
TETRAHYDROPALMATINE DERIVATIVE, ITS PREPARATION METHOD AND USE
Document Type and Number:
WIPO Patent Application WO/2017/080313
Kind Code:
A1
Abstract:
Provided a compound of formula (I): or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, and the compound is tetrahydropalmatine derivative. The compound has a use in preparation of a medicament, and the medicament is used for inhibiting proliferation of a cancer cell of a eukaryote and/or treating or preventing cancer.
Inventors:
ZHANG HONG (CN)
TANG YALIN (CN)
SHEN GANG (CN)
WANG LIXIA (CN)
YANG FENGMIN (CN)
TANG YALIN (CN)
SHEN GANG (CN)
WANG LIXIA (CN)
YANG FENGMIN (CN)
Application Number:
PCT/CN2016/099490
Publication Date:
May 18, 2017
Filing Date:
September 20, 2016
Export Citation:
Assignee:
INST CHEMISTRY CAS (CN)
International Classes:
C07H17/02; A61K31/706; A61P35/00; C07H1/00
Foreign References:
| CN101773499A | 2010-07-14 | |||
| CN101926797A | 2010-12-29 |
Other References:
GE, HAIXIA ET AL.: "Chemical and microbial semi-synthesis of tetrahydroprotoberberines as inhibitors on tissue factor procoagulant activity.", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, no. 1, 10 November 2012 (2012-11-10), pages 62 - 69, XP028961389
GE, HAIXIA ET AL.: "Biotransformation of tetrahydroprotoberberines by Panax ginseng hairy root culture.", JOURNAL OF MOLECULAR CATALYSIS B: ENZYMATIC, vol. 110, 16 October 2014 (2014-10-16), pages 133 - 139, XP055381763
SUN, YAN ET AL.: "Oral bioavailability and brain penetration of (-)-stepholidine, a tetrahydroprotoberberine agonist at dopamine D1 and antagonist at D2 receptors, in rats.", BRITISH JOURNAL OF PHARMACOLOGY, vol. 158, no. 5, 25 September 2009 (2009-09-25), pages 1302 - 1312, XP055381766
GE, HAIXIA ET AL.: "Biotransformation of tetrahydroprotoberberines by Panax ginseng hairy root culture.", JOURNAL OF MOLECULAR CATALYSIS B: ENZYMATIC, vol. 110, 16 October 2014 (2014-10-16), pages 133 - 139, XP055381763
SUN, YAN ET AL.: "Oral bioavailability and brain penetration of (-)-stepholidine, a tetrahydroprotoberberine agonist at dopamine D1 and antagonist at D2 receptors, in rats.", BRITISH JOURNAL OF PHARMACOLOGY, vol. 158, no. 5, 25 September 2009 (2009-09-25), pages 1302 - 1312, XP055381766
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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