Title:
TETRAHYDROQUINOLINE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO/2018/168818
Kind Code:
A1
Abstract:
The present invention relates to tetrahydroquinoline derivatives of the present invention or a pharmaceutically acceptable salt thereof or a prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders which are mediated via the P2X7 receptor.
Inventors:
NOGUCHI HIROHIDE (JP)
ARANO YOSHIMASA (JP)
ANDO KAZUO (JP)
TOYOSHIMA KAZUKI (JP)
SONE TOSHIHIKO (JP)
MATSUBARA KOKI (JP)
ARANO YOSHIMASA (JP)
ANDO KAZUO (JP)
TOYOSHIMA KAZUKI (JP)
SONE TOSHIHIKO (JP)
MATSUBARA KOKI (JP)
Application Number:
PCT/JP2018/009627
Publication Date:
September 20, 2018
Filing Date:
March 13, 2018
Export Citation:
Assignee:
RAQUALIA PHARMA INC (JP)
ASAHI KASEI PHARMA CORP (JP)
ASAHI KASEI PHARMA CORP (JP)
International Classes:
C07D215/48; A61K31/47; A61K31/4709; A61K31/4747; A61K31/5375; A61K31/5386; A61P9/06; A61P13/12; A61P19/00; A61P25/00; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07D215/20; C07D221/04; C07D401/06; C07D401/12; C07D405/12; C07D417/12; C07D491/08; C07D498/10; C07F7/18
Domestic Patent References:
WO2004106305A1 | 2004-12-09 | |||
WO2005009968A1 | 2005-02-03 | |||
WO2015187905A1 | 2015-12-10 | |||
WO2014097140A1 | 2014-06-26 | |||
WO2008124153A1 | 2008-10-16 | |||
WO2013108227A1 | 2013-07-25 | |||
WO2016039983A1 | 2016-03-17 | |||
WO2016019228A1 | 2016-02-04 |
Other References:
DATABASE FILE REGISTRY 16 July 1988 (1988-07-16), retrieved from STN Database accession no. 115271-77-7
DATABASE FILE REGISTRY 16 November 1984 (1984-11-16), retrieved from STN Database accession no. 58111-53-8
GUILE, S.D. ET AL., J. MED. CHEM, vol. 52, 2009, pages 3123 - 3141
GUNOSEWOYO, H.KASSIOU, M., EXP OPIN, vol. 20, 2010, pages 625 - 646
NORTH, R. A., PHYSIOL. REV., vol. 82, no. 4, 2002, pages 1013 - 67
SURPRENANT, A.RASSENDREN, F. ET AL., SCIENCE, vol. 272, no. 5262, 1996, pages 735 - 8
VIRGINIO, C.MACKENZIE, A. ET AL., J. PHYSIOL., vol. 519, 1999, pages 335 - 46
DUANNEARY, GLIA, vol. 54, 2006, pages 738 - 746
SKAPER ET AL., FASEB J, vol. 24, 2009, pages 337 - 345
SURPRENANTNORTH, ANNU. REV. PHYSIOL., vol. 71, 2009, pages 333 - 359
MULLER ET AL., AM. J. RESPIR. CELL MOL. BIOL., vol. 44, 2011, pages 456 - 464
FERRARI ET AL., J. IMMUNOL., vol. 176, 2006, pages 3877 - 3883
CHESSELL, I. P.HATCHER, J. P. ET AL., PAIN, vol. 114, no. 3, 2005, pages 386 - 396
BASSO ET AL., BEHAV. BRAIN RES., vol. 198, 2009, pages 83 - 90
DANTZER, IMMUNOL. ALLERGY CLIN. NORTH AM., vol. 29, 2009, pages 247 - 264
CAPURONMILLER, PHARMACOL. THER., vol. 130, 2011, pages 226 - 238
PARVATHENANI ET AL., J. BIOL. CHEM., vol. 278, 2003, pages 13309 - 13317
See also references of EP 3609868A4
DATABASE FILE REGISTRY 16 November 1984 (1984-11-16), retrieved from STN Database accession no. 58111-53-8
GUILE, S.D. ET AL., J. MED. CHEM, vol. 52, 2009, pages 3123 - 3141
GUNOSEWOYO, H.KASSIOU, M., EXP OPIN, vol. 20, 2010, pages 625 - 646
NORTH, R. A., PHYSIOL. REV., vol. 82, no. 4, 2002, pages 1013 - 67
SURPRENANT, A.RASSENDREN, F. ET AL., SCIENCE, vol. 272, no. 5262, 1996, pages 735 - 8
VIRGINIO, C.MACKENZIE, A. ET AL., J. PHYSIOL., vol. 519, 1999, pages 335 - 46
DUANNEARY, GLIA, vol. 54, 2006, pages 738 - 746
SKAPER ET AL., FASEB J, vol. 24, 2009, pages 337 - 345
SURPRENANTNORTH, ANNU. REV. PHYSIOL., vol. 71, 2009, pages 333 - 359
MULLER ET AL., AM. J. RESPIR. CELL MOL. BIOL., vol. 44, 2011, pages 456 - 464
FERRARI ET AL., J. IMMUNOL., vol. 176, 2006, pages 3877 - 3883
CHESSELL, I. P.HATCHER, J. P. ET AL., PAIN, vol. 114, no. 3, 2005, pages 386 - 396
BASSO ET AL., BEHAV. BRAIN RES., vol. 198, 2009, pages 83 - 90
DANTZER, IMMUNOL. ALLERGY CLIN. NORTH AM., vol. 29, 2009, pages 247 - 264
CAPURONMILLER, PHARMACOL. THER., vol. 130, 2011, pages 226 - 238
PARVATHENANI ET AL., J. BIOL. CHEM., vol. 278, 2003, pages 13309 - 13317
See also references of EP 3609868A4
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
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