Title:
TETRATHIOL LIGANDS, METAL COMPLEXES, CONJUGATES, AND KITS, THE USE THEREOF IN NUCLEAR MEDICINE DIAGNOSTICS AND ENDORADIONUCLIDE THERAPY, AND METHOD FOR PRODUCING THE TETRATHIOL LIGANDS AND METAL COMPLEXES
Document Type and Number:
WIPO Patent Application WO/2010/043218
Kind Code:
A3
Abstract:
The invention relates to a ligand of formula (I), where (CH-R1) and (CH-R1') are substituted or non-substituted methylene bridges; the individual R1 and R1', and R3 and R3', are each selected independently of each other from hydrogen, substituted or non-substituted alkyl groups, substituted or non-substituted aryl groups; and m and n are positive whole numbers, where m represents the number of (CH-R1') groups and n represents the number of (CH-R1) groups; wherein the sum of m and n is in the range from 4 to 10; R2 and R2' are selected independently of each other from hydrogen, substituted or non-substituted alkyl groups, substituted or non-substituted carboxyl groups, substituted or non-substituted aryl groups, or Z; X is a substituted or non-substituted methylene bridge having the formula CHR4 or a non-substituted amino group (N-H) or substituted amino group (N-Z); wherein Z stands for –(CH-R5)p-A, where (CH-R5) represents a substituted or non-substituted methylene bridge, and p is a whole number standing for the number of the (CH-R5) groups, wherein p is in the range from 2 through 8; A represents a linkable unit, wherein R4 and the individual R5 are each selected independently of each other from hydrogen, substituted or non-substituted alkyl groups, substituted or non-substituted aryl groups.
Inventors:
FOERSTER CHRISTIAN (DE)
PIETZSCH HANS-JUERGEN (DE)
SUHR MATTHIAS (DE)
PIETZSCH HANS-JUERGEN (DE)
SUHR MATTHIAS (DE)
Application Number:
PCT/DE2009/050056
Publication Date:
January 27, 2011
Filing Date:
October 16, 2009
Export Citation:
Assignee:
FORSCHUNGSZENTR DD ROSSENDORF (DE)
FOERSTER CHRISTIAN (DE)
PIETZSCH HANS-JUERGEN (DE)
SUHR MATTHIAS (DE)
FOERSTER CHRISTIAN (DE)
PIETZSCH HANS-JUERGEN (DE)
SUHR MATTHIAS (DE)
International Classes:
C07D295/185; A61K51/04; A61K51/08; C07D273/01; C07F1/08; C07F5/00; C07F7/22; C07F13/00
Domestic Patent References:
| WO2005108330A1 | 2005-11-17 |
Foreign References:
| US3397217A | 1968-08-13 | |||
| US5175256A | 1992-12-29 |
Other References:
W. DRABER: "Synthese von 1,4-Dithiinen aus Derivaten des Maleinimids", CHEM. BER., vol. 100, 1967, pages 1559 - 1570, XP002572791
D. WÖHRLE, G. MANECKE: "Synthese von Dimercaptomaleinsäuren und deren Umsetzung zu Metallkoordinationspolymeren mit Halbleitereigenschaften", DIE MAKROMOLEKULARE CHEMIE, vol. 140, 1970, pages 137 - 147, XP002572792
S. A. BAUDRON ET AL.: "A Straightforward Synthesis of Diverse Nickel Dithiolene Complexes Appended with Hydrogen-Bond Donor/Acceptor Groups", INORGANIC CHEMISTRY, vol. 44, no. 10, 15 April 2005 (2005-04-15), pages 3380 - 3382, XP002572793
M. NOMURA ET AL.: "Imido-transfer reactions to carbonyl moiety induced by the reactions of imido-bridged cobaltadithiolene complexes with trivalent phosphorus halides", J. ORGANOMET. CHEM., vol. 674, 2003, pages 63-72, XP002572794
H. OKU AT EL.: "Association of Oxo-Molybdenum Dithiolene Complexes with a Multiamide Additive and Its Influence on the Ease of O-Atom Transfer", INORG. CHEM., vol. 36, no. 7, 1997, pages 1504 - 1516, XP002572795
P. VELLA, J. ZUBIETA: "Electrochemical investigation of compounds possessing the CrS6 core", J. INORG. NUCL. CHEM., vol. 40, 1978, pages 613 - 624, XP002572796
D. WÖHRLE, G. MANECKE: "Synthese von Dimercaptomaleinsäuren und deren Umsetzung zu Metallkoordinationspolymeren mit Halbleitereigenschaften", DIE MAKROMOLEKULARE CHEMIE, vol. 140, 1970, pages 137 - 147, XP002572792
S. A. BAUDRON ET AL.: "A Straightforward Synthesis of Diverse Nickel Dithiolene Complexes Appended with Hydrogen-Bond Donor/Acceptor Groups", INORGANIC CHEMISTRY, vol. 44, no. 10, 15 April 2005 (2005-04-15), pages 3380 - 3382, XP002572793
M. NOMURA ET AL.: "Imido-transfer reactions to carbonyl moiety induced by the reactions of imido-bridged cobaltadithiolene complexes with trivalent phosphorus halides", J. ORGANOMET. CHEM., vol. 674, 2003, pages 63-72, XP002572794
H. OKU AT EL.: "Association of Oxo-Molybdenum Dithiolene Complexes with a Multiamide Additive and Its Influence on the Ease of O-Atom Transfer", INORG. CHEM., vol. 36, no. 7, 1997, pages 1504 - 1516, XP002572795
P. VELLA, J. ZUBIETA: "Electrochemical investigation of compounds possessing the CrS6 core", J. INORG. NUCL. CHEM., vol. 40, 1978, pages 613 - 624, XP002572796
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