Title:
THERAPEUTIC AGENT FOR DISEASE ASSOCIATED WITH ABNORMAL LIPID
Document Type and Number:
WIPO Patent Application WO/2022/244845
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel therapeutic agent for dyslipidemia, which targets angiopoietin-like factor 3. According to the present invention, a vaccine composition is provided, which contains a peptide having a portion of the sequence for angiopoietin-like factor 3 (ANGPTL3) as an active ingredient, in which the peptide comprises at least one peptide selected from the group consisting of EPKSRFA (SEQ ID NO: 3), EPKSRFAMLD (SEQ ID NO: 4) and EPKSRFAMLDDVK (SEQ ID NO: 5).
Inventors:
OIKE YUICHI (JP)
MORINAGA JUN (JP)
FUKAMI HIROTAKA (JP)
MORINAGA JUN (JP)
FUKAMI HIROTAKA (JP)
Application Number:
PCT/JP2022/020850
Publication Date:
November 24, 2022
Filing Date:
May 19, 2022
Export Citation:
Assignee:
UNIV KUMAMOTO NAT UNIV CORP (JP)
International Classes:
A61K39/00; A61K47/62; A61P1/16; A61P3/06; A61P9/10; C07K7/06; C07K7/08; C07K19/00
Domestic Patent References:
| WO2021001804A1 | 2021-01-07 | |||
| WO2019173719A1 | 2019-09-12 |
Foreign References:
| JP2010512320A | 2010-04-22 | |||
| JP2014527078A | 2014-10-09 |
Other References:
OIKE, YUICHI.: "Angiopoietin-like proteins and cardiovascular disease", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 268, no. 5, 1 January 2019 (2019-01-01), JP , pages 338 - 342, XP009541404, ISSN: 0039-2359
FOWLER ALEXANDRA; SAMPSON MAUREEN; REMALEY ALAN T.; CHACKERIAN BRYCE: "A VLP-based vaccine targeting ANGPTL3 lowers plasma triglycerides in mice", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 39, no. 40, 30 August 2021 (2021-08-30), AMSTERDAM, NL , pages 5780 - 5786, XP086779957, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2021.08.077
FUKAMI HIROTAKA, MORINAGA JUN, NAKAGAMI HIRONORI, HAYASHI HIROKI, OKADOME YUSUKE, MATSUNAGA EIJI, KADOMATSU TSUYOSHI, HORIGUCHI HA: "Vaccine targeting ANGPTL3 ameliorates dyslipidemia and associated diseases in mouse models of obese dyslipidemia and familial hypercholesterolemia", CELL REPORTS MEDICINE, vol. 2, no. 11, 1 November 2021 (2021-11-01), pages 100446, XP093007534, ISSN: 2666-3791, DOI: 10.1016/j.xcrm.2021.100446
FUKAMI, HIROTAKA ET AL. : "Selection of therapeutic candidates based on clinical research and development of dyslipidemia vaccines targeting angiopoietin-like protein 3 (ANGPTL3)", NIHON NAIKA GAKKAI ZASSHI - JOURNAL OF THE JAPANESE SOCIETY OFINTERNAL MEDICINE, NIHON NAIKA GAKKAI, TOKYO, JP, vol. 111, no. Sp. Issue, 20 February 2022 (2022-02-20) - 17 April 2022 (2022-04-17), JP , pages 170, XP009541599, ISSN: 0021-5384
FUKAMI, HIROTAKA ET AL.: "YIA1-9 Development of therapeutic vaccine for dyslipidemia and related diseases targeting angiopoietin-like factor 3 (ANGPTL3)", NIHON NAIBUNPI GAKKAI ZASSHI - FOLIA ENDOCRINOLOGICA JAPONICA, NIHON NAIBUNPI GAKKAI, JP, vol. 98, no. 1, 1 April 2022 (2022-04-01), JP , pages 272, XP009541598, ISSN: 0029-0661
FOWLER ALEXANDRA; SAMPSON MAUREEN; REMALEY ALAN T.; CHACKERIAN BRYCE: "A VLP-based vaccine targeting ANGPTL3 lowers plasma triglycerides in mice", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 39, no. 40, 30 August 2021 (2021-08-30), AMSTERDAM, NL , pages 5780 - 5786, XP086779957, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2021.08.077
FUKAMI HIROTAKA, MORINAGA JUN, NAKAGAMI HIRONORI, HAYASHI HIROKI, OKADOME YUSUKE, MATSUNAGA EIJI, KADOMATSU TSUYOSHI, HORIGUCHI HA: "Vaccine targeting ANGPTL3 ameliorates dyslipidemia and associated diseases in mouse models of obese dyslipidemia and familial hypercholesterolemia", CELL REPORTS MEDICINE, vol. 2, no. 11, 1 November 2021 (2021-11-01), pages 100446, XP093007534, ISSN: 2666-3791, DOI: 10.1016/j.xcrm.2021.100446
FUKAMI, HIROTAKA ET AL. : "Selection of therapeutic candidates based on clinical research and development of dyslipidemia vaccines targeting angiopoietin-like protein 3 (ANGPTL3)", NIHON NAIKA GAKKAI ZASSHI - JOURNAL OF THE JAPANESE SOCIETY OFINTERNAL MEDICINE, NIHON NAIKA GAKKAI, TOKYO, JP, vol. 111, no. Sp. Issue, 20 February 2022 (2022-02-20) - 17 April 2022 (2022-04-17), JP , pages 170, XP009541599, ISSN: 0021-5384
FUKAMI, HIROTAKA ET AL.: "YIA1-9 Development of therapeutic vaccine for dyslipidemia and related diseases targeting angiopoietin-like factor 3 (ANGPTL3)", NIHON NAIBUNPI GAKKAI ZASSHI - FOLIA ENDOCRINOLOGICA JAPONICA, NIHON NAIBUNPI GAKKAI, JP, vol. 98, no. 1, 1 April 2022 (2022-04-01), JP , pages 272, XP009541598, ISSN: 0029-0661
Attorney, Agent or Firm:
OSAWA Kenichi (JP)
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