Title:
COMPOSITION FOR REGULATING CELL PROLIFERATION AND REGULATION METHOD OF CELL PROLIFERATION
Document Type and Number:
WIPO Patent Application WO/2022/244846
Kind Code:
A1
Abstract:
The present invention provides a composition for regulating cell proliferation, said composition containing a regulator of D-amino acid content, or a composition that activates an mTOR-related pathway. The present invention also provides a regulation method of cell proliferation in a subject, said method comprising administering a regulator of D-amino acid content in vivo to a subject requiring the same. The present invention also provides a regulation method of cell proliferation in vitro or ex vivo, said method comprising a step for applying a regulator of D-amino acid content to a cell, a biological tissue or an organ and culturing. The present invention also provides a use of a regulator of D-amino acid content to produce a pharmaceutical composition for regulating cell proliferation.
Inventors:
KIMURA TOMONORI (JP)
HESAKA ATSUSHI (JP)
TSUKAMOTO YUSUKE (JP)
MITA MASASHI (JP)
HESAKA ATSUSHI (JP)
TSUKAMOTO YUSUKE (JP)
MITA MASASHI (JP)
Application Number:
PCT/JP2022/020851
Publication Date:
November 24, 2022
Filing Date:
May 19, 2022
Export Citation:
Assignee:
KAGAMI INC (JP)
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
NAT INST BIOMEDICAL INNOVATION HEALTH & NUTRITION (JP)
International Classes:
C12N5/07; A61K31/198; A61K45/00; A61P3/00; A61P13/12; A61P43/00; C12N15/53; C12N15/61
Domestic Patent References:
| WO2020218737A1 | 2020-10-29 | |||
| WO2019235592A1 | 2019-12-12 | |||
| WO2011087091A1 | 2011-07-21 | |||
| WO2021132691A1 | 2021-07-01 |
Foreign References:
| JP2015027265A | 2015-02-12 | |||
| JP2019214558A | 2019-12-19 | |||
| JP2005514069A | 2005-05-19 | |||
| JP2016510795A | 2016-04-11 | |||
| JP2015516456A | 2015-06-11 |
Other References:
SATO TSUTOMU, YAMOCHI TADANORI, YAMOCHI TOSHIKO, AYTAC UGUR, OHNUMA KEI, MCKEE KATHRYN S., MORIMOTO CHIKAO, DANG NAM H.: "CD26 Regulates p38 Mitogen-Activated Protein Kinase–Dependent Phosphorylation of Integrin β 1 , Adhesion to Extracellular Matrix, and Tumorigenicity of T-Anaplastic Large Cell Lymphoma Karpas 299", CANCER RESEARCH, vol. 65, no. 15, 1 August 2005 (2005-08-01), US, pages 6950 - 6956, XP055873919, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-05-0647
THIELITZ ANJA, ANSORGE SIEGFRIED, BANK UTE, TAGER MICHAEL, WRENGER SABINE, GOLLNICK HARALD, REINHOLD DIRK: "The ectopeptidases dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN) and their related enzymes as possible targets in the treatment of skin diseases", FRONTIERS IN BIOSCIENCE, vol. 13, no. 13, 1 January 2008 (2008-01-01), US , pages 2364 - 2375, XP093005632, ISSN: 1093-9946, DOI: 10.2741/2850
THIELITZ ANJA, ANSORGE SIEGFRIED, BANK UTE, TAGER MICHAEL, WRENGER SABINE, GOLLNICK HARALD, REINHOLD DIRK: "The ectopeptidases dipeptidyl peptidase IV (DP IV) and aminopeptidase N (APN) and their related enzymes as possible targets in the treatment of skin diseases", FRONTIERS IN BIOSCIENCE, vol. 13, no. 13, 1 January 2008 (2008-01-01), US , pages 2364 - 2375, XP093005632, ISSN: 1093-9946, DOI: 10.2741/2850
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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