Title:
THERAPEUTIC AGENT AND THERAPEUTIC METHOD WHICH ARE FOR CANCER PATIENTS EXHIBITING RB1 FUNCTIONAL DETERIORATION AND WHICH INVOLVE CONCOMITANT USE OF MYT1 INHIBITOR AND CHEMOTHERAPEUTIC AGENT
Document Type and Number:
WIPO Patent Application WO/2024/048687
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition that contains an MYT1 inhibitor as an active ingredient, that is for therapy or prevention of cancer in a patient exhibiting RB1 functional deterioration, and that is to be used in combination with a chemotherapeutic agent.
Inventors:
OHTE YUKI (JP)
SAKAMOTO HIROSHI (JP)
SUYAMA EIGO (JP)
OGASAWARA KIYOMOTO (JP)
SOGA MAYUMI (JP)
GOTO TAKAHIRO (JP)
SAKAMOTO HIROSHI (JP)
SUYAMA EIGO (JP)
OGASAWARA KIYOMOTO (JP)
SOGA MAYUMI (JP)
GOTO TAKAHIRO (JP)
Application Number:
PCT/JP2023/031636
Publication Date:
March 07, 2024
Filing Date:
August 30, 2023
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
A61K45/00; A61K31/437; A61K31/4745; A61K31/7068; A61K31/7105; A61K45/06; A61K48/00; A61P35/00; A61P43/00; C07K16/18; C12N15/113; C12Q1/02; C12Q1/6886; G01N33/15; G01N33/50
Domestic Patent References:
| WO2021195782A1 | 2021-10-07 | |||
| WO2021195781A1 | 2021-10-07 |
Foreign References:
| US20210316003A1 | 2021-10-14 |
Other References:
GALLO DAVID; YOUNG JORDAN T. F.; FOURTOUNIS JIMMY; MARTINO GIOVANNI; ÁLVAREZ-QUILÓN ALEJANDRO; BERNIER CYNTHIA; DUFFY NICOLE M.; P: "CCNE1 amplification is synthetic lethal with PKMYT1 kinase inhibition", NATURE, vol. 604, no. 7907, 20 April 2022 (2022-04-20), pages 749 - 756, XP037805455, DOI: 10.1038/s41586-022-04638-9
KONSTANTINOPOULOS PANAGIOTIS A; CHENG SU-CHUN; WAHNER HENDRICKSON ANDREA E; PENSON RICHARD T; SCHUMER SUSAN T; DOYLE L AUSTIN; LEE: "Berzosertib plus gemcitabine versus gemcitabine alone in platinum-resistant high-grade serous ovarian cancer: a multicentre, open-label, randomised, phase 2 trial", THE LANCET ONCOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 21, no. 7, 15 June 2020 (2020-06-15), AMSTERDAM, NL , pages 957 - 968, XP086205220, DOI: 10.1016/S1470-2045(20)30180-7
KNUDSEN ERIK S., KUMARASAMY VISHNU, NAMBIAR RAM, PEARSON JOEL D., VAIL PARIS, ROSENHECK HANNA, WANG JIANXIN, ENG KEVIN, BREMNER RO: "CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities", CELL REPORTS, ELSEVIER INC, US, vol. 38, no. 9, 1 March 2022 (2022-03-01), US , pages 110448, XP093144169, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2022.110448
LI HUIHUI, WANG LI, ZHANG WEI, DONG YOUTING, CAI YEFENG, HUANG XIAOLI, DONG XUBIN: "Overexpression of PKMYT1 associated with poor prognosis and immune infiltration may serve as a target in triple-negative breast cancer", FRONTIERS IN ONCOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 12, CH , XP093144171, ISSN: 2234-943X, DOI: 10.3389/fonc.2022.1002186
KONSTANTINOPOULOS PANAGIOTIS A; CHENG SU-CHUN; WAHNER HENDRICKSON ANDREA E; PENSON RICHARD T; SCHUMER SUSAN T; DOYLE L AUSTIN; LEE: "Berzosertib plus gemcitabine versus gemcitabine alone in platinum-resistant high-grade serous ovarian cancer: a multicentre, open-label, randomised, phase 2 trial", THE LANCET ONCOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 21, no. 7, 15 June 2020 (2020-06-15), AMSTERDAM, NL , pages 957 - 968, XP086205220, DOI: 10.1016/S1470-2045(20)30180-7
KNUDSEN ERIK S., KUMARASAMY VISHNU, NAMBIAR RAM, PEARSON JOEL D., VAIL PARIS, ROSENHECK HANNA, WANG JIANXIN, ENG KEVIN, BREMNER RO: "CDK/cyclin dependencies define extreme cancer cell-cycle heterogeneity and collateral vulnerabilities", CELL REPORTS, ELSEVIER INC, US, vol. 38, no. 9, 1 March 2022 (2022-03-01), US , pages 110448, XP093144169, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2022.110448
LI HUIHUI, WANG LI, ZHANG WEI, DONG YOUTING, CAI YEFENG, HUANG XIAOLI, DONG XUBIN: "Overexpression of PKMYT1 associated with poor prognosis and immune infiltration may serve as a target in triple-negative breast cancer", FRONTIERS IN ONCOLOGY, FRONTIERS RESEARCH FOUNDATION, CH, vol. 12, CH , XP093144171, ISSN: 2234-943X, DOI: 10.3389/fonc.2022.1002186
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Download PDF: