Title:
THERAPEUTIC AGENT FOR MUSCULAR ATROPHY
Document Type and Number:
WIPO Patent Application WO/2022/210802
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a novel agent for the prevention or treatment of muscular atrophy. The present invention provides an agent for the prevention or treatment of muscular atrophy, wherein the agent contains a Dll4 function inhibitor as an active ingredient. The Dll4 function inhibitor is selected from the group consisting of inhibitors of binding between Dll4 and Notch2, inhibitors of the expression of Dll4, or inhibitors of binding of collagen with LL4.
Inventors:
ONO YUSUKE (JP)
FUJIMAKI SHIN (JP)
FUJIMAKI SHIN (JP)
Application Number:
PCT/JP2022/015725
Publication Date:
October 06, 2022
Filing Date:
March 29, 2022
Export Citation:
Assignee:
UNIV KUMAMOTO NAT UNIV CORP (JP)
International Classes:
A61K45/00; A61K31/713; A61K39/395; A61K48/00; A61P21/00; A61P21/02; A61P21/04; A61P43/00
Foreign References:
| JP2013518122A | 2013-05-20 | |||
| KR20140028215A | 2014-03-10 |
Other References:
LIU CHONG; LI DONGXIAO; LV CUI; GAO ZHISONG; QI YINKUANG; WU HONGRAN; TIAN YUNYUN; GUO YANSU: "Activation of the Notch Signaling Pathway and Cellular Localization of Notch Signaling Molecules in the Spinal Cord of SOD1-G93A ALS Model Mice", NEUROSCIENCE, NEW YORK, NY, US, vol. 432, 28 February 2020 (2020-02-28), US , pages 84 - 93, XP086104375, ISSN: 0306-4522, DOI: 10.1016/j.neuroscience.2020.02.034
FUJIMAKI SHIN, MATSUMOTO TOMOHIRO, MURAMATSU MASASHI, NAGAHISA HIROSHI, HORII NAOKI, SEKO DAIKI, MASUDA SHINYA, WANG XUERUI, ASAKU: "The endothelial Dll4–muscular Notch2 axis regulates skeletal muscle mass", NATURE METABOLISM, vol. 4, no. 2, 1 February 2022 (2022-02-01), pages 180 - 189, XP055972449, DOI: 10.1038/s42255-022-00533-9
GERLI MATTIA FRANCESCO MARIA, MOYLE LOUISE ANNE, BENEDETTI SARA, FERRARI GIULIA, UCUNCU EKIN, RAGAZZI MARTINA, CONSTANTINOU CHRYST: "Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells", STEM CELL REPORTS, CELL PRESS, UNITED STATES, vol. 12, no. 3, 1 March 2019 (2019-03-01), United States , pages 461 - 473, XP055972445, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2019.01.007
FUJIMAKI SHIN, MATSUMOTO TOMOHIRO, MURAMATSU MASASHI, NAGAHISA HIROSHI, HORII NAOKI, SEKO DAIKI, MASUDA SHINYA, WANG XUERUI, ASAKU: "The endothelial Dll4–muscular Notch2 axis regulates skeletal muscle mass", NATURE METABOLISM, vol. 4, no. 2, 1 February 2022 (2022-02-01), pages 180 - 189, XP055972449, DOI: 10.1038/s42255-022-00533-9
GERLI MATTIA FRANCESCO MARIA, MOYLE LOUISE ANNE, BENEDETTI SARA, FERRARI GIULIA, UCUNCU EKIN, RAGAZZI MARTINA, CONSTANTINOU CHRYST: "Combined Notch and PDGF Signaling Enhances Migration and Expression of Stem Cell Markers while Inducing Perivascular Cell Features in Muscle Satellite Cells", STEM CELL REPORTS, CELL PRESS, UNITED STATES, vol. 12, no. 3, 1 March 2019 (2019-03-01), United States , pages 461 - 473, XP055972445, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2019.01.007
Attorney, Agent or Firm:
OSAWA Kenichi (JP)
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