Title:
THERAPEUTIC AGENT FOR NEURODEGENERATIVE DISORDER
Document Type and Number:
WIPO Patent Application WO/2023/163187
Kind Code:
A1
Abstract:
The present invention provides: an anti-gpNMB antibody that binds to gpNMB and affects the same and that has an effect of such as removal of dysfunctional microglia; and a use application of the anti-gpNMB antibody. The anti-gpNMB antibody specifically binds to at least one site in a region from a PMEL-CAF-like domain to a PKD domain of gpNMB.
Inventors:
EGUCHI HIROSHI (JP)
TOMIYAMA TAKAMI (JP)
UMEDA TOMOHIRO (JP)
TOMIYAMA TAKAMI (JP)
UMEDA TOMOHIRO (JP)
Application Number:
PCT/JP2023/007143
Publication Date:
August 31, 2023
Filing Date:
February 27, 2023
Export Citation:
Assignee:
TEIJIN PHARMA LTD (JP)
UNIV OSAKA PUBLIC CORP (JP)
UNIV OSAKA PUBLIC CORP (JP)
International Classes:
C07K16/28; A61K31/713; A61K35/12; A61K38/02; A61K39/395; A61K45/00; A61K48/00; A61P25/00; A61P25/28; A61P37/04; A61P43/00; C07K14/705; C07K16/46; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/06; C12N15/13; C12N15/63; C12P21/08
Foreign References:
| JP2021522277A | 2021-08-30 | |||
| US20020151486A1 | 2002-10-17 |
Other References:
KOHICHI KAWAHARA; HIROSHI HIRATA; KENGO OHBUCHI; KENTARO NISHI; AKIRA MAEDA; AKIHIKO KUNIYASU; DAISUKE YAMADA; TAKEHIKO MAEDA; AKI: "The novel monoclonal antibody 9F5 reveals expression of a fragment of GPNMB/osteoactivin processed by furin‐like protease(s) in a subpopulation of microglia in neonatal rat brain", GLIA, WILEY-LISS, INC., US, vol. 64, no. 11, 27 July 2016 (2016-07-27), US , pages 1938 - 1961, XP071740319, ISSN: 0894-1491, DOI: 10.1002/glia.23034
MELANIE HüTTENRAUCH;ISABELLA OGOREK;HANS KLAFKI;MARKUS OTTO;CHRISTINE STADELMANN;SASCHA WEGGEN;JENS WILTFANG;OLIVER WIRTHS: "Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia", ACTA NEUROPATHOLOGICA COMMUNICATIONS, BIOMED CENTRAL LTD, LONDON, UK, vol. 6, no. 1, 19 October 2018 (2018-10-19), London, UK , pages 1 - 14, XP021261727, DOI: 10.1186/s40478-018-0612-3
SATOH JUN-ICHI, KINO YOSHIHIRO, YANAIZU MOTOAKI, ISHIDA TSUYOSHI, SAITO YUKO: "Microglia express GPNMB in the brains of Alzheimer's disease and Nasu-Hakola disease", INTRACTABLE & RARE DISEASES RESEARCH, INTERNATIONAL ADVANCEMENT CENTER FOR MEDICINE & HEALTH RESEARCH CO., vol. 8, no. 2, 31 May 2019 (2019-05-31), pages 120 - 128, XP093085723, ISSN: 2186-3644, DOI: 10.5582/irdr.2019.01049
MELANIE HüTTENRAUCH;ISABELLA OGOREK;HANS KLAFKI;MARKUS OTTO;CHRISTINE STADELMANN;SASCHA WEGGEN;JENS WILTFANG;OLIVER WIRTHS: "Glycoprotein NMB: a novel Alzheimer’s disease associated marker expressed in a subset of activated microglia", ACTA NEUROPATHOLOGICA COMMUNICATIONS, BIOMED CENTRAL LTD, LONDON, UK, vol. 6, no. 1, 19 October 2018 (2018-10-19), London, UK , pages 1 - 14, XP021261727, DOI: 10.1186/s40478-018-0612-3
SATOH JUN-ICHI, KINO YOSHIHIRO, YANAIZU MOTOAKI, ISHIDA TSUYOSHI, SAITO YUKO: "Microglia express GPNMB in the brains of Alzheimer's disease and Nasu-Hakola disease", INTRACTABLE & RARE DISEASES RESEARCH, INTERNATIONAL ADVANCEMENT CENTER FOR MEDICINE & HEALTH RESEARCH CO., vol. 8, no. 2, 31 May 2019 (2019-05-31), pages 120 - 128, XP093085723, ISSN: 2186-3644, DOI: 10.5582/irdr.2019.01049
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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