Title:
THERAPEUTIC ANTI-BGP(C-CAM1) ANTIBODIES AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO2004024746
Kind Code:
A3
Abstract:
Provided are specific antibodies which are capable of modulating T cell activity and uses thereof. In particular, antibodies and binding fragments thereof are described, which react with a specific domain of biliary glycoprotein (BGP), also known as CD66a, CEACAM1 and C-CAM1, and which are capable of suppressing the cytolytic activity of intestinal intraepithelial lymphocytes (iIELs). Furthermore, compositions comprising said antibodies are provided and methods of modulating immune cell proliferation, and treating immune response related diseases.
Inventors:
BLUMBERG RICHARD S (US)
BHAN ATUL
BHAN ATUL
Application Number:
PCT/US2003/028416
Publication Date:
July 29, 2004
Filing Date:
September 11, 2003
Export Citation:
Assignee:
BRIGHAM & WOMENS HOSPITAL (US)
GEN HOSPITAL CORP (US)
BLUMBERG RICHARD S (US)
BHAN ATUL
GEN HOSPITAL CORP (US)
BLUMBERG RICHARD S (US)
BHAN ATUL
International Classes:
C07K16/28; C12N5/20; (IPC1-7): C07K16/00; C07H21/04; C07K16/28; C12N1/20; C12N5/20; C12N15/00
Foreign References:
| US4348376A | 1982-09-07 |
Other References:
MORALES, ET AL: "REGULATION OF HUMAN INTESTINAL INTRAEPITHELIAL LYMPHOCYTE CYTOLYTIC FUNCTION BY BILIARY GLYCOPROTEIN (CD66A)", J. IMMUNOL., vol. 163, no. 3, 1999, pages 1363 - 1370, XP002229265
WATT, ET AL: "HOMOPHILIC ADHESION OF HUMAN CEACAM1 INVOLVES N-TERMINAL DOMAIN INTERACTIONS: STRUCTURAL ANALYSIS OF THE BINDING SITE", BLOOD, vol. 98, no. 5, 1 September 2001 (2001-09-01), pages 1469 - 1479, XP002229281
WATT, ET AL: "HOMOPHILIC ADHESION OF HUMAN CEACAM1 INVOLVES N-TERMINAL DOMAIN INTERACTIONS: STRUCTURAL ANALYSIS OF THE BINDING SITE", BLOOD, vol. 98, no. 5, 1 September 2001 (2001-09-01), pages 1469 - 1479, XP002229281
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