Title:
THIOAPTAMERS ENABLE DISCOVERY OF PHYSIOLOGICAL PATHWAYS AND NEW THERAPEUTIC STRATEGIES
Document Type and Number:
WIPO Patent Application WO2005010016
Kind Code:
A3
Abstract:
A system and method for determining the effect of a target molecule within a physiological pathway is disclosed in which a thioaptamer is used to affect a detectable activity of the physiological pathway in a cell or cell fragment.
Inventors:
GORENSTEIN DAVID G (US)
LUXON BRUCE A (US)
LUXON BRUCE A (US)
Application Number:
PCT/US2004/023888
Publication Date:
June 29, 2006
Filing Date:
July 23, 2004
Export Citation:
Assignee:
REGENTS BOARD OF (US)
GORENSTEIN DAVID G (US)
LUXON BRUCE A (US)
GORENSTEIN DAVID G (US)
LUXON BRUCE A (US)
International Classes:
C07H21/02; A01N43/04; C07H21/04; C12N15/11; C12N15/85; C12P19/34; C12Q1/68; C07H
Other References:
LEBRUSKA ET AL.: "Selection and characterization of an RNA decoy for transcription factor NF-kappa B", BIOCHEMISTRY, vol. 38, 1999, pages 3168 - 3174, XP002923025
KING ET AL.: "Combinatorial selection and binding of phosphorothioate aptamers targeting human NF-kappa B RelA (p65) and p50", BIOCHEMISTRY, vol. 41, no. 30, 2002, pages 9696 - 9706, XP009084286
KING ET AL.: "Novel combinatorial selection of phosphorothioate oligonucleotide aptamers", BIOCHEMISTRY, vol. 37, no. 47, 1998, pages 16489 - 16493, XP002417200
BIELINSKA ET AL.: "Regulation of gene expression with double-stranded phosphorothioate oligonucleotides", SCIENCE, vol. 250, 1990, pages 997 - 1000, XP002065516
KHALED ET AL.: "Use of phosphorothioate-modified oligodeoxynucleotides to inhibit NF-kappa B expression and lymphocyte function", CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 86, no. 2, 1998, pages 170 - 179, XP009003515
ELBASHIR ET AL.: "RNA interference is mediated by 21- and 22-nucleotide RNAs", GENES AND DEVELOPMENT, vol. 15, no. 2, 2001, pages 188 - 200, XP002204651
KING ET AL.: "Combinatorial selection and binding of phosphorothioate aptamers targeting human NF-kappa B RelA (p65) and p50", BIOCHEMISTRY, vol. 41, no. 30, 2002, pages 9696 - 9706, XP009084286
KING ET AL.: "Novel combinatorial selection of phosphorothioate oligonucleotide aptamers", BIOCHEMISTRY, vol. 37, no. 47, 1998, pages 16489 - 16493, XP002417200
BIELINSKA ET AL.: "Regulation of gene expression with double-stranded phosphorothioate oligonucleotides", SCIENCE, vol. 250, 1990, pages 997 - 1000, XP002065516
KHALED ET AL.: "Use of phosphorothioate-modified oligodeoxynucleotides to inhibit NF-kappa B expression and lymphocyte function", CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, vol. 86, no. 2, 1998, pages 170 - 179, XP009003515
ELBASHIR ET AL.: "RNA interference is mediated by 21- and 22-nucleotide RNAs", GENES AND DEVELOPMENT, vol. 15, no. 2, 2001, pages 188 - 200, XP002204651
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