Title:
THIOBENZIMIDAZOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/191536
Kind Code:
A1
Abstract:
The present invention relates to a thiobenzimidazole derivative or a pharmaceutically acceptable salt thereof, and a composition for preventing or treating cancer, the composition comprising the derivative as an active ingredient. The thiobenzimidazole derivative according to the present invention inhibits tubulin polymerization by being activated in cancer cells, and exhibits cytotoxicity by blocking the cell cycle of cancer cells and inducing apoptosis when administered to an individual, and thus can be used for preventing or treating cancer and preferably, for preventing or treating HER-2 positive breast cancer or triple-negative breast cancer.
Inventors:
SEO JAE HONG (KR)
NAM KEE DAL (KR)
KIM JI YOUNG (KR)
KIM YOON JAE (KR)
KANG YONG KOO (KR)
NAM KEE DAL (KR)
KIM JI YOUNG (KR)
KIM YOON JAE (KR)
KANG YONG KOO (KR)
Application Number:
PCT/KR2023/004258
Publication Date:
October 05, 2023
Filing Date:
March 30, 2023
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
C07D409/12; A61K31/4184; A61K31/454; A61K31/496; A61K31/541; A61P35/00; C07D235/32; C07D491/113
Domestic Patent References:
| WO2020127946A2 | 2020-06-25 | |||
| WO2001083457A2 | 2001-11-08 | |||
| WO2022086110A1 | 2022-04-28 |
Foreign References:
| US20120064008A1 | 2012-03-15 |
Other References:
AGUAYO-ORTIZ RODRIGO, CANO-GONZáLEZ LUCIA, CASTILLO RAFAEL, HERNáNDEZ-CAMPOS ALICIA, DOMINGUEZ LAURA: "Structure-based approaches for the design of benzimidazole-2-carbamate derivatives as tubulin polymerization inhibitors", CHEMICAL BIOLOGY & DRUG DESIGN, BLACKWELL MUNKSGAARD, HOBOKEN, USA, vol. 90, no. 1, 1 July 2017 (2017-07-01), Hoboken, USA, pages 40 - 51, XP055846436, ISSN: 1747-0277, DOI: 10.1111/cbdd.12926
DOGRA NILAMBRA, KUMAR ASHOK, MUKHOPADHYAY TAPAS: "Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways", SCIENTIFIC REPORTS, vol. 8, no. 1, 1 December 2018 (2018-12-01), XP055778295, DOI: 10.1038/s41598-018-30158-6
DOGRA NILAMBRA, KUMAR ASHOK, MUKHOPADHYAY TAPAS: "Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways", SCIENTIFIC REPORTS, vol. 8, no. 1, 1 December 2018 (2018-12-01), XP055778295, DOI: 10.1038/s41598-018-30158-6
Attorney, Agent or Firm:
MUHANN PATENT & LAW FIRM (KR)
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