Title:
THREE-DIMENSIONAL FLOW PATH STRUCTURE BODY AND METHOD OF PRODUCING NANOPARTICLES USING SAME
Document Type and Number:
WIPO Patent Application WO/2021/064998
Kind Code:
A1
Abstract:
The present invention pertains to a flow path structure body for forming self-assembling molecular particles. The flow path structure body has a base body and a flow path structure provided to the interior thereof, the flow path structure having a first introduction channel 10 and a second introduction channel 20 that are independent of one another on the upstream side of the flow path structure, and the introduction channels merging at a merging site. The flow path structure has a dilution flow path 40 that is bent three-dimensionally toward the downstream side of the merging site. The dilution flow path 40 has two or more Y-structure elements 50 that protrude out in a Y-direction and one or more Z-structure elements 60 that protrude out in a Z-direction within the dilution flow path, and at least two adjacent Y-structure elements protrude out alternately in the Y-direction. The present invention pertains to a method of producing self-assembling molecular particles, whereby a self-assembling molecule-containing solution and a dilution medium are supplied to the flow path structure body to form self-assembling molecular particles that have encapsulated a substance to be encapsulated. The present invention provides: a method of producing self-assembling molecular nanoparticles that enables precise control of the particle size of self-assembling molecular nanoparticles that have encapsulated an anionic molecule or the like at a high encapsulation rate; and a flow path structure body used for production.
Inventors:
MAEKI MASATOSHI (JP)
TOKESHI MANABU (JP)
HARASHIMA HIDEYOSHI (JP)
SATO YUSUKE (JP)
KIMURA NIKO (JP)
TOKESHI MANABU (JP)
HARASHIMA HIDEYOSHI (JP)
SATO YUSUKE (JP)
KIMURA NIKO (JP)
Application Number:
PCT/JP2019/039347
Publication Date:
April 08, 2021
Filing Date:
October 04, 2019
Export Citation:
Assignee:
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
B01J13/04; A61K9/127; C12N15/113
Other References:
KIMURA NIKO, MAEKI MASATOSHI, SATO YUSUKE, NOTE YUSUKE, ISHIDA AKIHIKO, TANI HIROFUMI, HARASHIMA HIDEYOSHI, TOKESHI MANABU: "Development of the iLiNP Device: Fine Tuning the Lipid Nanoparticle Size within 10nm for Drug Delivery", ACS OMEGA, vol. 3, no. 5, 9 May 2018 (2018-05-09), pages 5044 - 5051, XP055810726
LIU R.H., STREMLER M.A., SHARP K.V., OLSEN M.G., SANTIAGO J.G., ADRIAN R.J., AREF H., BEEBE D.J.: "Passive Mixing in a Three-Dimensional Serpentine MicroChannel", JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, vol. 9, no. 2, 1 June 2000 (2000-06-01), pages 190 - 197, XP011450833
ANSARI M A; KIM K Y: "Parametric study on mixing of two fluids in a three-dimensional serpentine microchannel", CHEMICAL ENGINEERING JOURNAL, vol. 146, no. 3, 15 February 2009 (2009-02-15), pages 439 - 448, XP025883081, DOI: 10.1016/j.cej.2008.10.006
LIU R.H., STREMLER M.A., SHARP K.V., OLSEN M.G., SANTIAGO J.G., ADRIAN R.J., AREF H., BEEBE D.J.: "Passive Mixing in a Three-Dimensional Serpentine MicroChannel", JOURNAL OF MICROELECTROMECHANICAL SYSTEMS, vol. 9, no. 2, 1 June 2000 (2000-06-01), pages 190 - 197, XP011450833
ANSARI M A; KIM K Y: "Parametric study on mixing of two fluids in a three-dimensional serpentine microchannel", CHEMICAL ENGINEERING JOURNAL, vol. 146, no. 3, 15 February 2009 (2009-02-15), pages 439 - 448, XP025883081, DOI: 10.1016/j.cej.2008.10.006
Attorney, Agent or Firm:
SIKS & CO. (JP)
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