Title:
TISSUE FIBROSIS INHIBITOR IN WHICH BIOCOMPATIBLE POLYMER IS USED
Document Type and Number:
WIPO Patent Application WO/2021/020576
Kind Code:
A1
Abstract:
A problem to be solved by the present invention is to provide a fibrosis inhibitor that solves the problem of inhibiting fibrosis of an organ or tissue surface, and especially of inhibiting fibrosis of an epicardial surface. Furthermore, by inhibiting fibrosis, the present invention prevents or reduces subsequent development of adhesions to avoid organ or tissue damage during re-operation. Provided is a fibrosis inhibitor for inhibiting fibrosis of a tissue by fixing a biocompatible polymer to a tissue where it is desirable to inhibit fibrosis.
Inventors:
SAGA HIDEKI (JP)
INUI MINAKO (JP)
OGURA NORIKO (JP)
INUI MINAKO (JP)
OGURA NORIKO (JP)
Application Number:
PCT/JP2020/029532
Publication Date:
February 04, 2021
Filing Date:
July 31, 2020
Export Citation:
Assignee:
KM BIOLOGICS CO LTD (JP)
International Classes:
A61L27/22; A61K35/12; A61K35/22; A61K35/30; A61K35/34; A61K35/36; A61K35/38; A61K35/50; A61K38/36; A61L27/36; A61L27/58; A61P9/00; A61P43/00
Domestic Patent References:
| WO2016143746A1 | 2016-09-15 |
Foreign References:
| JPH06508356A | 1994-09-22 | |||
| JP2003528026A | 2003-09-24 | |||
| JPH11502431A | 1999-03-02 | |||
| JP2001327592A | 2001-11-27 | |||
| JP2003500170A | 2003-01-07 | |||
| JP4092397B2 | 2008-05-28 | |||
| JP2008111530A | 2008-05-15 | |||
| JP2009050297A | 2009-03-12 |
Other References:
MORO, H. ET AL.: "The effect of fibrin glue on inhibition of pericardial adhesions", THE JAPANESE JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, vol. 47, 1999, pages 79 - 84, XP019925843, DOI: 10.1007/BF03217946
FUNAMOTO SEIICHI, HASHIMOTO YOSHIHIDE, KISHIDA AKIO, NEGISHI JUN: "A fibrin-coated pericardial extracellular matrix prevented heart adhesion in a rat model", J BIOMED MATER RES PART B., vol. 107, no. 4, 19 September 2018 (2018-09-19), pages 1088 - 1094, XP055789327
TSUNEO FUKUSHIMA ET AL., SURGICAL THERAPY, vol. 94, no. 6, 2006, pages 919 - 924
UYAMA N ET AL., SCI REP, vol. 9, no. 1, 2019, pages 17558
DOBELL AR ET AL., ANN THORAC SURG., vol. 37, 1984, pages 273 - 8
OZEREN M ET AL., CARDIOVASC. SURG., vol. 10, no. 5, 2002, pages 489 - 493
TETSUYA KITAGAWA, PEDIATRIC CARDIOLOGY AND CARDIAC SURGERY, vol. 20, no. 6, 2004, pages 632 - 633
LIERMANN A ET AL., HELV CHIR ACTA, vol. 58, 1992, pages 515 - 519
MURALIDHARAN S ET AL., J BIOMED MATER RES, vol. 25, 1991, pages 1201 - 1209
BUNTON RW ET AL., J THORAC CARDIOVASC SURG, vol. 100, 1990, pages 99 - 107
JUKKA T ET AL., INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, vol. 12, no. 2, 2011, pages 270 - 272
KAUSHAL S ET AL., THORAC CARDIOVASC SURG, vol. 141, 2011, pages 789 - 795
NAITO Y ET AL., J THORAC CARDIOVASC SURG, vol. 135, 2008, pages 850 - 856
TAKAMICHI SATO ET AL., OBSTETRICS AND GYNECOLOGY, vol. 57, no. 12, 1990, pages 2398 - 2404
KIYOSHI OKUDA ET AL., THE WORLD OF OBSTETRICS AND GYNECOLOGY, vol. 45, no. 9, 1993, pages 759 - 764
AKIO KISHIDA, ORGAN BIOLOGY, vol. 25, no. 1, 2018, pages 27 - 34
SINGELYN J.M. ET AL., BIOMATERIALS, vol. 30, 2009, pages 5409 - 5416
SINGELYN J.M ET AL., J. AM. COLL., vol. 59, 2012, pages 751 - 763
SONYA B. ET AL., SCI. TRANSL. MED., vol. 5, 2013, pages 173 - 25
SASAKI S. ET AL., MOL. VIS., vol. 15, 2009, pages 2022 - 2028
YOSHIHIDE H. ET AL., BIOMATERIALS, vol. 31, 2010, pages 3590 - 3595
NEGISHI J. ET AL., J. ARTIF. ORGANS, vol. 14, 2011, pages 223 - 231
HIRASHIMA M. ET AL., J. BIOCHEM., vol. 159, 2016, pages 261 - 270
META A. ET AL., J. BIOSCI. BIOENG, vol. 120, 2015, pages 432 - 437
See also references of EP 4008368A4
FUNAMOTO SEIICHI, HASHIMOTO YOSHIHIDE, KISHIDA AKIO, NEGISHI JUN: "A fibrin-coated pericardial extracellular matrix prevented heart adhesion in a rat model", J BIOMED MATER RES PART B., vol. 107, no. 4, 19 September 2018 (2018-09-19), pages 1088 - 1094, XP055789327
TSUNEO FUKUSHIMA ET AL., SURGICAL THERAPY, vol. 94, no. 6, 2006, pages 919 - 924
UYAMA N ET AL., SCI REP, vol. 9, no. 1, 2019, pages 17558
DOBELL AR ET AL., ANN THORAC SURG., vol. 37, 1984, pages 273 - 8
OZEREN M ET AL., CARDIOVASC. SURG., vol. 10, no. 5, 2002, pages 489 - 493
TETSUYA KITAGAWA, PEDIATRIC CARDIOLOGY AND CARDIAC SURGERY, vol. 20, no. 6, 2004, pages 632 - 633
LIERMANN A ET AL., HELV CHIR ACTA, vol. 58, 1992, pages 515 - 519
MURALIDHARAN S ET AL., J BIOMED MATER RES, vol. 25, 1991, pages 1201 - 1209
BUNTON RW ET AL., J THORAC CARDIOVASC SURG, vol. 100, 1990, pages 99 - 107
JUKKA T ET AL., INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY, vol. 12, no. 2, 2011, pages 270 - 272
KAUSHAL S ET AL., THORAC CARDIOVASC SURG, vol. 141, 2011, pages 789 - 795
NAITO Y ET AL., J THORAC CARDIOVASC SURG, vol. 135, 2008, pages 850 - 856
TAKAMICHI SATO ET AL., OBSTETRICS AND GYNECOLOGY, vol. 57, no. 12, 1990, pages 2398 - 2404
KIYOSHI OKUDA ET AL., THE WORLD OF OBSTETRICS AND GYNECOLOGY, vol. 45, no. 9, 1993, pages 759 - 764
AKIO KISHIDA, ORGAN BIOLOGY, vol. 25, no. 1, 2018, pages 27 - 34
SINGELYN J.M. ET AL., BIOMATERIALS, vol. 30, 2009, pages 5409 - 5416
SINGELYN J.M ET AL., J. AM. COLL., vol. 59, 2012, pages 751 - 763
SONYA B. ET AL., SCI. TRANSL. MED., vol. 5, 2013, pages 173 - 25
SASAKI S. ET AL., MOL. VIS., vol. 15, 2009, pages 2022 - 2028
YOSHIHIDE H. ET AL., BIOMATERIALS, vol. 31, 2010, pages 3590 - 3595
NEGISHI J. ET AL., J. ARTIF. ORGANS, vol. 14, 2011, pages 223 - 231
HIRASHIMA M. ET AL., J. BIOCHEM., vol. 159, 2016, pages 261 - 270
META A. ET AL., J. BIOSCI. BIOENG, vol. 120, 2015, pages 432 - 437
See also references of EP 4008368A4
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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