TISSUE-SPECIFIC AND PATHOGEN-SPECIFIC TOXIC AGENTS, RIBOZYMES, DNAZYMES AND ANTISENSE OLIGONUCLEOTIDES, AND METHODS OF USE THEREOF

Title:

TISSUE-SPECIFIC AND PATHOGEN-SPECIFIC TOXIC AGENTS, RIBOZYMES, DNAZYMES AND ANTISENSE OLIGONUCLEOTIDES, AND METHODS OF USE THEREOF

Document Type and Number:

WIPO Patent Application WO2001079524

Kind Code:

A3

Abstract:

The present invention relates to the discovery, identification and characterization of toxic agents which are lethal to pathogens and methods for targeting such toxic agents to a pathogen or pathogen infected cells in order to treat and/or eradicate the infection. In particular, the present invention relates to toxic agents which target bacteria at different stages of the bacterial life cycle, which are delivered alone or in combination to bacteria or bacteria-infected cells. The invention relates to toxic agents which are lethal to diseased cells and methods for targeting such toxic agent to a diseased cell in order to treat and/or eradicate the disease. The present invention relates to promoter elements which are pathogen-specific or tissue-specific and the use of such promoter elements to achieve pathogen-specific or tissue-specific expression of the toxic agent(s) and/or ribozyme(s) of the present invention. Specifically, the invention relates to the delivery of one or more toxic gene products, antisense RNAs, or ribozymes, or combination thereof. The invention provides a novel system by which multiple pathogenic targets may be simultaneously targeted to cause the death of a pathogen, or cell infected with a pathogen. Further, the invention has important implications in the eradication of drug-resistant bacterium and bacterial pathogens. The invention provides a novel system by which multiple targets may be simultaneously targeted to cause the death of a diseased cell. The invention has important implications in the eradication of drug-resistant pathogens (such as antibiotic resistant bacteria) and drug-resistant diseased cells (such as drug-resistant cancer cells).

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Inventors:

NORRIS JAMES S (US)
CLAWSON GARY A (US)
WESTWATER CAROLINE (US)
SCHOFIELD DAVID (US)
SCHMIDT MICHAEL G (US)
HOEL BRIAN (US)
DOLAN JOSEPH (US)
PAN WEI-HUA (US)

Application Number:

PCT/US2001/012130

Publication Date:

January 08, 2004

Filing Date:

April 13, 2001

Export Citation:

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Assignee:

UNIV SOUTH CAROLINA (US)
PENN STATE RES FOUND (US)
NORRIS JAMES S (US)
CLAWSON GARY A (US)
WESTWATER CAROLINE (US)
SCHOFIELD DAVID (US)
SCHMIDT MICHAEL G (US)
HOEL BRIAN (US)
DOLAN JOSEPH (US)
PAN WEI-HUA (US)

International Classes:

C12N15/09; A61K9/06; A61K9/127; A61K31/7088; A61K31/7105; A61K47/42; A61K48/00; A61P1/16; A61P15/00; A61P17/12; A61P31/04; A61P31/12; A61P33/00; A61P35/00; C12N9/00; C12N15/113; C12N15/74; A61K38/00; (IPC1-7): C12N15/00; A61K48/00; C12Q1/68

Foreign References:

US6015694A	2000-01-18
US5989804A	1999-11-23
US6004513A	1999-12-21

Other References: