Title:
TRANSDERMAL ESTRADIOL DELIVERY SYSTEM
Document Type and Number:
WIPO Patent Application WO/1993/010772
Kind Code:
A1
Abstract:
The invention is represented by a transdermal medicated patch for the extended release of 17beta-estradiol to the skin. The transdermal patch is formed by an outer covering, a matrix containing from 1 % to 5 % (w/w) 17beta-estradiol, and a protective liner which is removed before use. The matrix is formed of pressure sensitive adhesive acrylic copolymers, in which the active ingredient is dissolved or dispersed. The acrylic copolymers are obtained by radical polymerization of 2-ethylhexyl acrylate, methyl acrylate, acrylic acid, vinyl acetate, hydroxyethyl acrylate or a mixture thereof. Optionally quantities of less than 0.5 % (w/w) of other substances may be added.
Inventors:
ROVATI LUIGI (IT)
ROVATI LUCIO (IT)
MAKOVEC FRANCESCO (IT)
CORDES GUENTER (DE)
FISCHER WILFRIED (DE)
ROVATI LUCIO (IT)
MAKOVEC FRANCESCO (IT)
CORDES GUENTER (DE)
FISCHER WILFRIED (DE)
Application Number:
PCT/EP1992/002704
Publication Date:
June 10, 1993
Filing Date:
November 24, 1992
Export Citation:
Assignee:
ROTTA RESEARCH LAB (IT)
International Classes:
A61K9/70; A61K31/565; C07J1/00; (IPC1-7): A61K9/70; A61K31/565
Domestic Patent References:
| WO1989007951A1 | 1989-09-08 |
Foreign References:
| EP0484543B1 | 1995-12-13 |
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