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Title:
TRANSPOSON SYSTEM, KIT COMPRISING THE SAME, AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/101749
Kind Code:
A1
Abstract:
An in vitro method for integrating an exogenous DNA sequence into the genome of a cell using a transposon system. The transposon system includes a first vector carrying inverted repeat sequences and an exogenous DNA, and a second vector that expresses a transposase. Also provided is a kit including the transposon system for integrating an exogenous DNA into the genome of a cell. A method for treating a subject is described that includes engineering an immune cell to carry an exogenous DNA sequence using the method and/or the kit described above and administering an effective amount of the engineered immune cell to the subject.

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Inventors:
WU SAREINA CHIUNG-YUAN (CN)
Application Number:
PCT/CN2016/109510
Publication Date:
June 22, 2017
Filing Date:
December 12, 2016
Export Citation:
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Assignee:
WU SAREINA CHIUNG-YUAN (CN)
International Classes:
C12N15/87; A61K48/00
Domestic Patent References:
WO2015157579A22015-10-15
Foreign References:
CN102943092A2013-02-27
CN101297031A2008-10-29
CN102421902A2012-04-18
US20020173634A12002-11-21
US20090042297A12009-02-12
Other References:
MEIR, Y.J. ET AL.: "A versatile, highly efficient, and potentially safer piggyBac transposon system for mammalian genome manipulations", THE FASEB JOURNAL, vol. 27, no. 11, 29 July 2013 (2013-07-29), pages 4429 - 4443, XP055392156
XIE, F. ET AL.: "Current advance of piggyBac in mammals and mammalian cells", CHINESE BULLETIN OF LIFE SCIENCES, vol. 23, no. 3, 31 March 2011 (2011-03-31), pages 255 - 260, XP009505977
Attorney, Agent or Firm:
CHINA ZHENGHE INTELLECTUAL PROPERTY AGENCY (CN)
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