Title:
TREATING CANCER
Document Type and Number:
WIPO Patent Application WO/2012/172341
Kind Code:
A3
Abstract:
A method for treating cancer comprising applying peripheral blood from a patient or subject to an apheresis column loaded with a solid support comprising one or more binding reagents capable of specifically binding to a chemokine receptor, optionally the chemokine receptor CCR7, CCR5, CCR6, CCR8, CXCR4, CXCR7, CCR4, CCR9, CCR10, CXCR3 or CXCR5 or to a Treg receptor immobilized directly or indirectly on the support thus removing one or more chemokine receptor, optionally CCR7, CCR5, CCR6, CCR8, CXCR4, CXCR7, CCR4, CCR9, CCR10, CXCR3 or CXCR5 or Treg receptor expressing cells from the peripheral blood of the patient or subject. Various companion diagnostic methods and useful binding reagents are also described.
Inventors:
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
WINQVIST OLA (SE)
Application Number:
PCT/GB2012/051351
Publication Date:
March 07, 2013
Filing Date:
June 13, 2012
Export Citation:
Assignee:
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
ITH IMMUNE THERAPY HOLDINGS (SE)
WINQVIST OLA (SE)
ITH IMMUNE THERAPY HOLDINGS (SE)
International Classes:
A61M1/36; B01J20/32
Domestic Patent References:
| WO2010029317A2 | 2010-03-18 | |||
| WO2012112724A1 | 2012-08-23 |
Foreign References:
| EP2067495A1 | 2009-06-10 |
Other References:
1 January 2010 (2010-01-01), XP055036910, Retrieved from the Internet [retrieved on 20120831]
IWAO TAKANAMI: "Overexpression of CCR7 mRNA in nonsmall cell lung cancer: Correlation with lymph node metastasis", INTERNATIONAL JOURNAL OF CANCER, vol. 105, no. 2, 10 June 2003 (2003-06-10), pages 186 - 189, XP055037030, ISSN: 0020-7136, DOI: 10.1002/ijc.11063
IWAO TAKANAMI: "Overexpression of CCR7 mRNA in nonsmall cell lung cancer: Correlation with lymph node metastasis", INTERNATIONAL JOURNAL OF CANCER, vol. 105, no. 2, 10 June 2003 (2003-06-10), pages 186 - 189, XP055037030, ISSN: 0020-7136, DOI: 10.1002/ijc.11063
Attorney, Agent or Firm:
SPENCER, Matthew (70 Gray's Inn RoadLondon, Greater London WC1X 8BT, GB)
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