Title:
TREATING MENTAL DISORDERS
Document Type and Number:
WIPO Patent Application WO/2012/172340
Kind Code:
A3
Abstract:
A method for treating mental disorders such as schizophrenia, depression and bipolar disorder comprises applying peripheral blood from a patient or subject to an apheresis column loaded with a solid support comprising a binding reagent capable of specifically binding to a chemokine receptor, optionally the chemokine receptor CCR9, CCR1, CCR3 and/or CCR5 immobilized directly or indirectly on the support thus removing chemokine receptor, optionally CCR9, CCR1, CCR3 and/or CCR5 expressing cells from the peripheral blood of the patient or subject. Various companion diagnostic methods and useful binding reagents are also described.
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Inventors:
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
WINQVIST OLA (SE)
Application Number:
PCT/GB2012/051350
Publication Date:
March 07, 2013
Filing Date:
June 13, 2012
Export Citation:
Assignee:
ITH IMMUNE THERAPY HOLDINGS (SE)
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
International Classes:
C07K14/52; A61M1/36; B01J20/32; C07K17/02; G01N33/68
Domestic Patent References:
| WO2007133147A1 | 2007-11-22 | |||
| WO2010029317A2 | 2010-03-18 | |||
| WO2007024705A2 | 2007-03-01 |
Foreign References:
| DE102005036505A1 | 2006-06-01 | |||
| EP2118060A1 | 2009-11-18 | |||
| US20100029753A1 | 2010-02-04 |
Other References:
TEIXEIRA ET AL: "Increased serum levels of CCL11/eotaxin in schizophrenia", PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, OXFORD, GB, vol. 32, no. 3, 23 November 2007 (2007-11-23), pages 710 - 714, XP022508051, ISSN: 0278-5846, DOI: 10.1016/J.PNPBP.2007.11.019
REALE MARCELLA ET AL: "Dysregulation of chemo-cytokine production in schizophrenic patients versus healthy controls", BMC NEUROSCIENCE, BIOMED CENTRAL, LONDON, GB, vol. 12, no. 1, 25 January 2011 (2011-01-25), pages 13, XP021086680, ISSN: 1471-2202, DOI: 10.1186/1471-2202-12-13
HSING-CHENG LIU ET AL: "Immunologic variables in acute mania of bipolar disorder", JOURNAL OF NEUROIMMUNOLOGY, vol. 150, no. 1-2, 1 May 2004 (2004-05-01), pages 116 - 122, XP055036823, ISSN: 0165-5728, DOI: 10.1016/j.jneuroim.2004.01.006
BELLANI M ET AL: "ALTERED MRNA LEVELS OF CHEMOKINES AND CYTOKINES IN SCHIZOPHRENIA AND BIPOLAR DISORDER", SCHIZOPHRENIA RESEARCH, ELSEVIER, NETHERLANDS, vol. 117, no. 2-3, 1 April 2010 (2010-04-01), pages 251 - 252, XP026979785, ISSN: 0920-9964, [retrieved on 20100320], DOI: 10.1016/J.SCHRES.2010.02.390
WAN-JIUNG HU: "Schizophrenia is a TH2 Dominant Autoimmune Disease Possibly Against Acetylcholine Receptors of CNS", VIXRA.ORG, vol. 1204, 0070, 30 April 2012 (2012-04-30), XP002682729, Retrieved from the Internet [retrieved on 20120903]
WOUTER BEUMER ET AL: "Increased level of serum cytokines, chemokines and adipokines in patients with schizophrenia is associated with disease and metabolic syndrome", PSYCHONEUROENDOCRINOLOGY, 1 April 2012 (2012-04-01), XP055036803, ISSN: 0306-4530, DOI: 10.1016/j.psyneuen.2012.04.001
REALE MARCELLA ET AL: "Dysregulation of chemo-cytokine production in schizophrenic patients versus healthy controls", BMC NEUROSCIENCE, BIOMED CENTRAL, LONDON, GB, vol. 12, no. 1, 25 January 2011 (2011-01-25), pages 13, XP021086680, ISSN: 1471-2202, DOI: 10.1186/1471-2202-12-13
HSING-CHENG LIU ET AL: "Immunologic variables in acute mania of bipolar disorder", JOURNAL OF NEUROIMMUNOLOGY, vol. 150, no. 1-2, 1 May 2004 (2004-05-01), pages 116 - 122, XP055036823, ISSN: 0165-5728, DOI: 10.1016/j.jneuroim.2004.01.006
BELLANI M ET AL: "ALTERED MRNA LEVELS OF CHEMOKINES AND CYTOKINES IN SCHIZOPHRENIA AND BIPOLAR DISORDER", SCHIZOPHRENIA RESEARCH, ELSEVIER, NETHERLANDS, vol. 117, no. 2-3, 1 April 2010 (2010-04-01), pages 251 - 252, XP026979785, ISSN: 0920-9964, [retrieved on 20100320], DOI: 10.1016/J.SCHRES.2010.02.390
WAN-JIUNG HU: "Schizophrenia is a TH2 Dominant Autoimmune Disease Possibly Against Acetylcholine Receptors of CNS", VIXRA.ORG, vol. 1204, 0070, 30 April 2012 (2012-04-30), XP002682729, Retrieved from the Internet
WOUTER BEUMER ET AL: "Increased level of serum cytokines, chemokines and adipokines in patients with schizophrenia is associated with disease and metabolic syndrome", PSYCHONEUROENDOCRINOLOGY, 1 April 2012 (2012-04-01), XP055036803, ISSN: 0306-4530, DOI: 10.1016/j.psyneuen.2012.04.001
Attorney, Agent or Firm:
SPENCER, Matthew (70 Gray's Inn RoadLondon, Greater London WC1X 8BT, GB)
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