Title:
TREATING CONDITIONS ASSOCIATED WITH ALLERGY
Document Type and Number:
WIPO Patent Application WO/2012/172345
Kind Code:
A3
Abstract:
A method for treating an allergic condition comprises applying peripheral blood from a patient or subject to an apheresis column loaded with a solid support comprising a binding reagent capable of specifically binding to a chemokine receptor, optionally the chemokine receptor CCR3, CXCR1, CXCR2 and/or CCR2 immobilized directly or indirectly on the support thus removing chemokine receptor, optionally CCR3, CXCR1, CXCR2 and/or CCR2 expressing cells from the peripheral blood of the patient or subject. Various companion diagnostic methods and useful binding reagents are also described.
Inventors:
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
WINQVIST OLA (SE)
Application Number:
PCT/GB2012/051355
Publication Date:
March 07, 2013
Filing Date:
June 13, 2012
Export Citation:
Assignee:
ITH IMMUNE THERAPY HOLDINGS (SE)
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
International Classes:
C07K14/52; A61M1/36; B01J20/32; C07K17/02; G01N33/48
Domestic Patent References:
| WO2007133147A1 | 2007-11-22 | |||
| WO2010029317A2 | 2010-03-18 | |||
| WO2008059066A1 | 2008-05-22 |
Foreign References:
| DE102005036505A1 | 2006-06-01 | |||
| US20030017979A1 | 2003-01-23 |
Other References:
NIKHIL YAWALKAR ET AL: "Enhanced Expression of Eotaxin and CCR3 in Atopic Dermatitis", JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 113, no. 1, 1 July 1999 (1999-07-01), pages 43 - 48, XP055038047, ISSN: 0022-202X, DOI: 10.1046/j.1523-1747.1999.00619.x
T J WILLIAMS ET AL: "Eotaxin and CCR3 as therapeutic targets in asthma and allergy", CHEMOKINES 2, 1 January 2003 (2003-01-01), Paris, XP055038313, Retrieved from the Internet [retrieved on 20120917]
DAVID CHANTRY ET AL: "Chemokines in Allergy", CURRENT DRUG TARGETS- INFLAMMATION & ALLERGY, vol. 1, no. 1, 1 January 2002 (2002-01-01), pages 109 - 116, XP055038300
PEASE JAMES E: "Asthma, allergy and chemokines", CURRENT DRUG TARGETS, vol. 7, no. 1, 1 January 2006 (2006-01-01), pages 3 - 12, XP008156147, ISSN: 1389-4501, Retrieved from the Internet [retrieved on 20120913]
T J WILLIAMS ET AL: "Eotaxin and CCR3 as therapeutic targets in asthma and allergy", CHEMOKINES 2, 1 January 2003 (2003-01-01), Paris, XP055038313, Retrieved from the Internet
DAVID CHANTRY ET AL: "Chemokines in Allergy", CURRENT DRUG TARGETS- INFLAMMATION & ALLERGY, vol. 1, no. 1, 1 January 2002 (2002-01-01), pages 109 - 116, XP055038300
PEASE JAMES E: "Asthma, allergy and chemokines", CURRENT DRUG TARGETS, vol. 7, no. 1, 1 January 2006 (2006-01-01), pages 3 - 12, XP008156147, ISSN: 1389-4501, Retrieved from the Internet
Attorney, Agent or Firm:
SPENCER, Matthew (70 Gray's Inn RoadLondon, Greater London WC1X 8BT, GB)
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