Title:
TREATING CONDITIONS ASSOCIATED WITH SEPSIS
Document Type and Number:
WIPO Patent Application WO/2012/172344
Kind Code:
A3
Abstract:
A method for treating sepsis and/or respiratory distress syndrome (RDS) comprises applying peripheral blood from a patient or subject to an apheresis column loaded with a solid support comprising one or more binding reagents capable of specifically binding to a chemokine receptor, optionally the chemokine receptor CCR5, CXCR1, CXCR2, and/or CCR2 immobilized directly or indirectly on the support thus removing one or more chemokine receptor, optionally CCR5, CXCR1, CXCR2, and/or CCR2 expressing cells from the peripheral blood of the patient or subject. Various companion therapeutic methods and useful binding reagents are also described.
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Inventors:
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
WINQVIST OLA (SE)
Application Number:
PCT/GB2012/051354
Publication Date:
March 14, 2013
Filing Date:
June 13, 2012
Export Citation:
Assignee:
ITH IMMUNE THERAPY HOLDINGS (SE)
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
International Classes:
C07K14/52; A61M1/36; B01J20/32; C07K17/02; G01N33/68
Domestic Patent References:
| WO2007133147A1 | 2007-11-22 | |||
| WO2010029317A2 | 2010-03-18 | |||
| WO2006052723A2 | 2006-05-18 |
Foreign References:
| DE102005036505A1 | 2006-06-01 | |||
| US20030017979A1 | 2003-01-23 | |||
| US20070092484A1 | 2007-04-26 |
Other References:
F. O. SOUTO ET AL: "Essential Role of CCR2 in Neutrophil Tissue Infiltration and Multiple Organ Dysfunction in Sepsis", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 183, no. 2, 15 January 2011 (2011-01-15), pages 234 - 242, XP055037727, ISSN: 1073-449X, DOI: 10.1164/rccm.201003-0416OC
AN J L ET AL: "Immunohistochemical detection of CCR2 and CX3CR1 in sepsis-induced lung injury", FORENSIC SCIENCE INTERNATIONAL, ELSEVIER SCIENTIFIC PUBLISHERS IRELAND LTD, IE, vol. 192, no. 1-3, 20 November 2009 (2009-11-20), pages e21 - e25, XP026669683, ISSN: 0379-0738, [retrieved on 20090904], DOI: 10.1016/J.FORSCIINT.2009.08.007
SPEYER CECILIA L ET AL: "Novel chemokine responsiveness and mobilization of neutrophils during sepsis", AMERICAN JOURNAL OF PATHOLOGY, vol. 165, no. 6, December 2004 (2004-12-01), pages 2187 - 2196, XP055037768, ISSN: 0002-9440
BOSSINK A W J ET AL: "Plasma Levels of the Chemokines Monocyte Chemotactic Protein-1 and -2 Are Elevated in Human Sepsis", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 86, no. 10, 15 November 1995 (1995-11-15), pages 3841 - 3847, XP002963170, ISSN: 0006-4971
AN J L ET AL: "Immunohistochemical detection of CCR2 and CX3CR1 in sepsis-induced lung injury", FORENSIC SCIENCE INTERNATIONAL, ELSEVIER SCIENTIFIC PUBLISHERS IRELAND LTD, IE, vol. 192, no. 1-3, 20 November 2009 (2009-11-20), pages e21 - e25, XP026669683, ISSN: 0379-0738, [retrieved on 20090904], DOI: 10.1016/J.FORSCIINT.2009.08.007
SPEYER CECILIA L ET AL: "Novel chemokine responsiveness and mobilization of neutrophils during sepsis", AMERICAN JOURNAL OF PATHOLOGY, vol. 165, no. 6, December 2004 (2004-12-01), pages 2187 - 2196, XP055037768, ISSN: 0002-9440
BOSSINK A W J ET AL: "Plasma Levels of the Chemokines Monocyte Chemotactic Protein-1 and -2 Are Elevated in Human Sepsis", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 86, no. 10, 15 November 1995 (1995-11-15), pages 3841 - 3847, XP002963170, ISSN: 0006-4971
Attorney, Agent or Firm:
SPENCER, Matthew (70 Gray's Inn RoadLondon, Greater London WC1X 8BT, GB)
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