Title:
TREATING INFLAMMATORY ARTHRITIS
Document Type and Number:
WIPO Patent Application WO/2012/172339
Kind Code:
A3
Abstract:
A method for treating inflammatory arthritis comprises applying peripheral blood from a patient or subject to an apheresis column loaded with a solid support comprising one or more binding reagents capable of specifically binding to a chemokine receptor, optionally the chemokine receptor CCR2, CCR1, CCR3 or CCR5 immobilized directly or indirectly on the support thus removing one or more chemokine receptor, optionally CCR2, CCR1, CCR3 and CCR5 expressing cells from the peripheral blood of the patient or subject. Various companion diagnostic methods and useful binding reagents are also described.
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Inventors:
WINQVIST OLA (SE)
COTTON GRAHAM (GB)
COTTON GRAHAM (GB)
Application Number:
PCT/GB2012/051348
Publication Date:
March 07, 2013
Filing Date:
June 13, 2012
Export Citation:
Assignee:
ITH IMMUNE THERAPY HOLDINGS (SE)
WINQVIST OLA (SE)
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
COTTON GRAHAM (GB)
International Classes:
C07K14/52; A61M1/36; B01J20/32; C07K17/02; G01N33/68
Domestic Patent References:
| WO2007133147A1 | 2007-11-22 | |||
| WO2010029317A2 | 2010-03-18 | |||
| WO2010021697A2 | 2010-02-25 |
Foreign References:
| DE102005036505A1 | 2006-06-01 | |||
| US20030017979A1 | 2003-01-23 | |||
| US20030215421A1 | 2003-11-20 |
Other References:
M. N. SARAFI ET AL: "Murine Monocyte Chemoattractant Protein (MCP)-5: A Novel CC Chemokine That Is a Structural and Functional Homologue of Human MCP-1", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 185, no. 1, 1 January 1997 (1997-01-01), pages 99 - 110, XP055035882, ISSN: 0022-1007, DOI: 10.1084/jem.185.1.99
TAKUJI IWAMOTO ET AL: "Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients", FEBS JOURNAL, vol. 275, no. 18, 1 September 2008 (2008-09-01), pages 4448 - 4455, XP055036303, ISSN: 1742-464X, DOI: 10.1111/j.1742-4658.2008.06580.x
L TYLASKA: "CCR2 REGULATES THE LEVEL OF MCP-1/CCL2 IN VITRO AND AT INFLAMMATORY SITES AND CONTROLS T CELL ACTIVATION IN RESPONSE TO ALLOANTIGEN", CYTOKINE, vol. 18, no. 4, 1 May 2002 (2002-05-01), pages 184 - 190, XP055035952, ISSN: 1043-4666, DOI: 10.1006/cyto.2002.1031
VERGUNST CLARISSA E ET AL: "Modulation of CCR2 in rheumatoid arthritis - A double-blind, randomized, placebo-controlled clinical trial", ARTHRITIS & RHEUMATISM, JOHN WILEY & SONS, INC, US, vol. 58, no. 7, 1 July 2008 (2008-07-01), pages 1931 - 1939, XP002676223, ISSN: 0004-3591, DOI: 10.1002/ART.23591
TAKUJI IWAMOTO ET AL: "Molecular aspects of rheumatoid arthritis: chemokines in the joints of patients", FEBS JOURNAL, vol. 275, no. 18, 1 September 2008 (2008-09-01), pages 4448 - 4455, XP055036303, ISSN: 1742-464X, DOI: 10.1111/j.1742-4658.2008.06580.x
L TYLASKA: "CCR2 REGULATES THE LEVEL OF MCP-1/CCL2 IN VITRO AND AT INFLAMMATORY SITES AND CONTROLS T CELL ACTIVATION IN RESPONSE TO ALLOANTIGEN", CYTOKINE, vol. 18, no. 4, 1 May 2002 (2002-05-01), pages 184 - 190, XP055035952, ISSN: 1043-4666, DOI: 10.1006/cyto.2002.1031
VERGUNST CLARISSA E ET AL: "Modulation of CCR2 in rheumatoid arthritis - A double-blind, randomized, placebo-controlled clinical trial", ARTHRITIS & RHEUMATISM, JOHN WILEY & SONS, INC, US, vol. 58, no. 7, 1 July 2008 (2008-07-01), pages 1931 - 1939, XP002676223, ISSN: 0004-3591, DOI: 10.1002/ART.23591
Attorney, Agent or Firm:
SPENCER, Matthew (70 Gray's Inn Road, London Greater London WC1X 8BT, GB)
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