Title:
TREATING MULTIPLE SCLEROSIS
Document Type and Number:
WIPO Patent Application WO/2012/172342
Kind Code:
A3
Abstract:
A method for treating multiple sclerosis comprises applying peripheral blood from a patient or subject to an apheresis column loaded with a solid support comprising one or more binding reagents capable of specifically binding to a chemokine receptor, optionally the chemokine receptor CCR2, CCR6, CCR3, CCR5, CCR1, CXCR3 and/or CCR9 immobilized directly or indirectly on the support thus removing one or more chemokine receptor, optionally CCR2, CCR6, CCR3, CCR5, CCR1, CXCR3 and/or CCR9 expressing cells from the peripheral blood of the patient or subject. Various companion diagnostic methods and useful binding reagents are also described.
Inventors:
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
WINQVIST OLA (SE)
Application Number:
PCT/GB2012/051352
Publication Date:
March 07, 2013
Filing Date:
June 13, 2012
Export Citation:
Assignee:
ITH IMMUNE THERAPY HOLDINGS (SE)
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
International Classes:
C07K14/52; A61M1/36; B01J20/32; C07K17/02; G01N33/68
Domestic Patent References:
| WO2007133147A1 | 2007-11-22 | |||
| WO2010029317A2 | 2010-03-18 | |||
| WO2005037305A1 | 2005-04-28 | |||
| WO2010103517A1 | 2010-09-16 |
Foreign References:
| DE102005036505A1 | 2006-06-01 | |||
| US20030215421A1 | 2003-11-20 | |||
| EP1783227A1 | 2007-05-09 |
Other References:
M. N. SARAFI ET AL: "Murine Monocyte Chemoattractant Protein (MCP)-5: A Novel CC Chemokine That Is a Structural and Functional Homologue of Human MCP-1", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 185, no. 1, 1 January 1997 (1997-01-01), pages 99 - 110, XP055035882, ISSN: 0022-1007, DOI: 10.1084/jem.185.1.99
CARLA IARLORI ET AL: "Interferon beta-1b modulates MCP-1 expression and production in relapsing-remitting multiple sclerosis.", JOURNAL OF NEUROIMMUNOLOGY, vol. 123, no. 1-2, 1 February 2002 (2002-02-01), pages 170 - 179, XP055037172, ISSN: 0165-5728
NAKAJIMA: "Increased intrathecal chemokine receptor CCR2 expression in multiple sclerosis", BIOMARKER INSIGHTS, vol. 2, 1 January 2007 (2007-01-01), pages 463, XP055037155, ISSN: 1177-2719
CARLA IARLORI ET AL: "Interferon beta-1b modulates MCP-1 expression and production in relapsing-remitting multiple sclerosis.", JOURNAL OF NEUROIMMUNOLOGY, vol. 123, no. 1-2, 1 February 2002 (2002-02-01), pages 170 - 179, XP055037172, ISSN: 0165-5728
NAKAJIMA: "Increased intrathecal chemokine receptor CCR2 expression in multiple sclerosis", BIOMARKER INSIGHTS, vol. 2, 1 January 2007 (2007-01-01), pages 463, XP055037155, ISSN: 1177-2719
Attorney, Agent or Firm:
SPENCER, Matthew (70 Gray's Inn RoadLondon, Greater London WC1X 8BT, GB)
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