Title:
TREATING PRIMARY SCLEROSING CHOLANGITIS
Document Type and Number:
WIPO Patent Application WO/2012/172343
Kind Code:
A3
Abstract:
A method for treating primary sclerosing cholangitis comprises applying peripheral blood from a patient or subject to an apheresis column loaded with a solid support comprising one or more binding reagents capable of specifically binding to a chemokine receptor, optionally the chemokine receptor CCR9, CXCR4, CCR7 or CCR5 immobilized directly or indirectly on the support thus removing one or more chemokine receptor, optionally CCR9, CXCR4, CCR7 and CCR5 expressing cells from the peripheral blood of the patient or subject. Various companion therapeutic methods and useful binding reagents are also described.
Inventors:
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
WINQVIST OLA (SE)
Application Number:
PCT/GB2012/051353
Publication Date:
March 07, 2013
Filing Date:
June 13, 2012
Export Citation:
Assignee:
ITH IMMUNE THERAPY HOLDINGS (SE)
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
COTTON GRAHAM (GB)
WINQVIST OLA (SE)
International Classes:
C07K14/52; A61M1/36; B01J20/32; C07K17/02; G01N33/68
Domestic Patent References:
| WO2007133147A1 | 2007-11-22 | |||
| WO2010029317A2 | 2010-03-18 | |||
| WO2006126209A1 | 2006-11-30 |
Foreign References:
| DE102005036505A1 | 2006-06-01 | |||
| US20030017979A1 | 2003-01-23 |
Other References:
B. EKSTEEN ET AL: "Hepatic Endothelial CCL25 Mediates the Recruitment of CCR9+ Gut-homing Lymphocytes to the Liver in Primary Sclerosing Cholangitis", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 200, no. 11, 6 December 2004 (2004-12-06), pages 1511 - 1517, XP055037419, ISSN: 0022-1007, DOI: 10.1084/jem.20041035
GRANT ALLISTER J ET AL: "Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease", AMERICAN JOURNAL OF PATHOLOGY, vol. 160, no. 4, April 2002 (2002-04-01), pages 1445 - 1455, XP002683083, ISSN: 0002-9440
TERADA RYO ET AL: "Stromal cell-derived factor-1 from biliary epithelial cells recruits CXCR4-positive cells: implications for inflammatory liver diseases", LABORATORY INVESTIGATION, NATURE PUBLISHING GROUP, THE UNITED STATES AND CANADIAN ACADEMY OF PALHOLOGY, INC, vol. 83, no. 5, 1 May 2003 (2003-05-01), pages 665 - 672, XP008155843, ISSN: 0023-6837, DOI: DOI:10.1097/01.LAB.0000067498.89585.06
ANDREA T BORCHERS ET AL: "Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis", SEMINARS IN IMMUNOPATHOLOGY, SPRINGER, BERLIN, DE, vol. 31, no. 3, 17 June 2009 (2009-06-17), pages 309 - 322, XP019758214, ISSN: 1863-2300, DOI: 10.1007/S00281-009-0167-2
GRANT ALLISTER J ET AL: "Hepatic expression of secondary lymphoid chemokine (CCL21) promotes the development of portal-associated lymphoid tissue in chronic inflammatory liver disease", AMERICAN JOURNAL OF PATHOLOGY, vol. 160, no. 4, April 2002 (2002-04-01), pages 1445 - 1455, XP002683083, ISSN: 0002-9440
TERADA RYO ET AL: "Stromal cell-derived factor-1 from biliary epithelial cells recruits CXCR4-positive cells: implications for inflammatory liver diseases", LABORATORY INVESTIGATION, NATURE PUBLISHING GROUP, THE UNITED STATES AND CANADIAN ACADEMY OF PALHOLOGY, INC, vol. 83, no. 5, 1 May 2003 (2003-05-01), pages 665 - 672, XP008155843, ISSN: 0023-6837, DOI: DOI:10.1097/01.LAB.0000067498.89585.06
ANDREA T BORCHERS ET AL: "Lymphocyte recruitment and homing to the liver in primary biliary cirrhosis and primary sclerosing cholangitis", SEMINARS IN IMMUNOPATHOLOGY, SPRINGER, BERLIN, DE, vol. 31, no. 3, 17 June 2009 (2009-06-17), pages 309 - 322, XP019758214, ISSN: 1863-2300, DOI: 10.1007/S00281-009-0167-2
Attorney, Agent or Firm:
SPENCER, Matthew (70 Gray's Inn RoadLondon, Greater London WC1X 8BT, GB)
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