Title:
TREATMENT AND DIAGNOSIS OF INSULIN RESISTANT STATES
Document Type and Number:
WIPO Patent Application WO2003032810
Kind Code:
A3
Abstract:
Dickkopf-5 (Dkk-5) protein is administered in effective amounts to treat disorders involving insulin resistance, such as non-insulin-dependent diabetes mellitus (NIDDM) or obesity (Figure 13). Also provided is a method of diagnosing insulin resistance and related disorders using Dkk-5 as a measure, and kits for diagnosis and treatment, as well as hybridomas producing antibodies to Dkk-5 and preparations comprising Dkk-5.
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Inventors:
DEALMEIDA VENITA I
STEWART TIMOTHY A
STEWART TIMOTHY A
Application Number:
PCT/US2002/032874
Publication Date:
June 17, 2004
Filing Date:
October 15, 2002
Export Citation:
Assignee:
GENENTECH INC (US)
International Classes:
G01N33/53; A61K31/175; A61K31/64; A61K38/00; A61K38/17; A61K38/18; A61K38/22; A61K38/28; A61K45/00; A61P3/04; A61P3/10; C07K14/435; C07K14/47; C07K16/18; C07K16/46; C12N5/10; C12N5/12; C12N15/09; C12P21/08; C12Q1/25; G01N33/537; G01N33/543; G01N33/567; G01N33/577; G01N33/68; A61B; A61K; A61P; C12N; G01N; (IPC1-7): A61K38/00
Other References:
SEMENOV et al., "Head inducer Dickkopf-1 is a ligan for Wnt coreceptor LRP6", Curr. Biol. June 2001, Vol. 11, No. 12, pages 951-961
BOYDEN et al., "High Bone Density Due to a Mutation in LDL-Receptor-Related Proteins 5", N. Engl. J. Med. 2002, Vol. 346, pages 1513-1521
BOYDEN et al., "High Bone Density Due to a Mutation in LDL-Receptor-Related Proteins 5", N. Engl. J. Med. 2002, Vol. 346, pages 1513-1521
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