MODULATION OF AKT-DEPENDENT RESPONSE TO PREVENT RESTENOSIS

Title:

MODULATION OF AKT-DEPENDENT RESPONSE TO PREVENT RESTENOSIS

Document Type and Number:

WIPO Patent Application WO2003032809

Kind Code:

A3

Abstract:

Restenosis of vessels after angioplasty, and narrowing of implanted blood vessels, such as arteries, veins, vascular grafts, and conduits, following implantation, is prevented or alleviated by inhibiting or modifying Akt activity in the cells of the vessel. The inhibition of Akt activity is achieved by administering to the blood vessel wall an effective amount of an agent capable of inhibiting Akt activity. The Akt inhibitor may be coated on a stent that is positioned within the blood vessel.

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Inventors:

EPSTEIN STEPHEN E (US)
FUCHS SHMUEL (US)
STABILE EUGENIO (US)

Application Number:

PCT/US2002/032617

Publication Date:

March 18, 2004

Filing Date:

October 15, 2002

Export Citation:

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Assignee:

MEDSTAR RES INST (US)
EPSTEIN STEPHEN E (US)
FUCHS SHMUEL (US)
STABILE EUGENIO (US)

International Classes:

A01K67/027; A61K38/00; C07H21/04; C12N15/86; C12Q1/68; A61K48/00; A61B; (IPC1-7): C07H21/04; A61K38/00; A61K48/00; C12N15/86; C12Q1/68

Other References:

STABILE ET AL.: "Dominant negative mutant AKT-dependent phosphorylation of p70 S6K and smooth muscle cell proliferation in vitro and reduces neointimal development in the rat carotid artery", CIRCULATION, vol. 104, no. 17, SUPPL., 23 October 2001 (2001-10-23), pages II.315 - II.316, XP002965071
CHARLES ET AL.: "Ceramide-coated balloon catheters limit neointimal hyperplasia after stretch injury in carotid arteries", CIRCULATION RESEARCH, vol. 87, no. 4, 18 August 2000 (2000-08-18), pages 282 - 288, XP002190356
VIRMANI ET AL.: "Drug eluting stents: are human and animal studies comparable", HEART JOURNAL, vol. 89, September 2002 (2002-09-01), pages 133 - 138, XP002965072

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