Title:
TREATMENT OF NERVE DAMAGE USING 5'UTR OF GPR151 GENE OR VARIANT THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/177369
Kind Code:
A1
Abstract:
Disclosed is a composition for treating neurological diseases caused by nerve damage comprising an isolated polynucleotide of 5'UTR (untranslated region) of Gpr151 gene or a variant thereof. Also, disclosed are novel variant polynucleotides of 5'UTR of Gpr151 gene, and vectors comprising the polynucleotides.
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Inventors:
CHO YONGCHEOL (KR)
SHIN JUNG EUN (KR)
LEE JIN-YOUNG (KR)
LEE BOHM (KR)
JEON YE-WON (KR)
SHIN JUNG EUN (KR)
LEE JIN-YOUNG (KR)
LEE BOHM (KR)
JEON YE-WON (KR)
Application Number:
PCT/KR2022/002459
Publication Date:
August 25, 2022
Filing Date:
February 18, 2022
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
A61K48/00; A61K31/7088; A61P25/28; C07K14/47; C12N15/86
Domestic Patent References:
| WO2009141066A1 | 2009-11-26 |
Foreign References:
| US20070231263A1 | 2007-10-04 |
Other References:
DATABASE NUCLEOTIDE 3 May 2022 (2022-05-03), ANONYMOUS : "Homo sapiens G protein-coupled receptor 151 (GPR151), mRNA", XP055959750, retrieved from NCBI Database accession no. NM_194251
BROMS JONAS, MATILDA GRAHM, LEA HAUGEGAARD, THOMAS BLOM, KONSTANTINOS MELETIS, ANDERS TINGSTRÖM : "Monosynaptic retrograde tracing of neurons expressing the G‐protein coupled receptor Gpr151 in the mouse brain", JOURNAL OF COMPARATIVE NEUROLOGY, vol. 525, no. 15, 24 July 2017 (2017-07-24), pages 3227 - 3250, XP055959758, DOI: 10.1002/cne.24273
LEE BOHM, LEE JINYOUNG, JEON YEWON, JANG EUNSOO, OH YEONSOO, KIM HYEMIN, KWON MINJAE, SHIN JUNG EUN, CHO YONGCHEOL: "Promoting axon regeneration by enhancing the non-coding function of the injury-responsive coding gene Gpr151", BIORXIV, 14 August 2021 (2021-08-14), XP055959762, DOI: 10.1101/2021.02.19.431965
BROMS JONAS, MATILDA GRAHM, LEA HAUGEGAARD, THOMAS BLOM, KONSTANTINOS MELETIS, ANDERS TINGSTRÖM : "Monosynaptic retrograde tracing of neurons expressing the G‐protein coupled receptor Gpr151 in the mouse brain", JOURNAL OF COMPARATIVE NEUROLOGY, vol. 525, no. 15, 24 July 2017 (2017-07-24), pages 3227 - 3250, XP055959758, DOI: 10.1002/cne.24273
LEE BOHM, LEE JINYOUNG, JEON YEWON, JANG EUNSOO, OH YEONSOO, KIM HYEMIN, KWON MINJAE, SHIN JUNG EUN, CHO YONGCHEOL: "Promoting axon regeneration by enhancing the non-coding function of the injury-responsive coding gene Gpr151", BIORXIV, 14 August 2021 (2021-08-14), XP055959762, DOI: 10.1101/2021.02.19.431965
Attorney, Agent or Firm:
PANKOREA PATENT AND LAW FIRM (KR)
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