TRIFLUOROMETHYLTHIOPHENIUM DERIVATIVE SALTS, PROCESS FOR PRODUCITON THEREOF, AND PROCESS FOR PRODUCTION OF TRIFLUOROMETHYL-CONTAINING COMPOUNDS USING SAME

Title:

TRIFLUOROMETHYLTHIOPHENIUM DERIVATIVE SALTS, PROCESS FOR PRODUCITON THEREOF, AND PROCESS FOR PRODUCTION OF TRIFLUOROMETHYL-CONTAINING COMPOUNDS USING SAME

Document Type and Number:

WIPO Patent Application WO/2011/013307

Kind Code:

A1

Abstract:

Provided are trifluoromethylthiophenium derivative salts useful as intermediates in the synthesis of drugs or agricultural chemicals, a process for production of the same, and a process for the production of trifluoromethyl-containing compounds using the same. Specifically provided are S-(trifluoromethyl) -benzo[b]thiophenium derivative salts represented by general formula (1), a process for the production of the same, and a process for the production of various trifluoromethyl -containing compounds using the same as the trifluoromethylating agent. In general formula (1), R1, R2, R3 and R4 are each independently a hydrogen atom, a methyl group, an ethyl group, a straight-chain, branched or cyclic C3-10 alkyl group, a methoxy group, an ethoxy group, a straight-chain, branched or cyclic C3-10 alkyloxy group, a fluorine atom, a chlorine atom, a bromine atom, a nitro group, or a cyano group; R5 is a methyl group, an ethyl group, a straight-chain, branched or cyclic C3-10 alkyl group, a phenyl group, or a substituted phenyl group; and X- is an anion.

Inventors:

SHIBATA NORIO (JP)
KAGAWA TAKUMI (JP)

Application Number:

PCT/JP2010/004518

Publication Date:

February 03, 2011

Filing Date:

July 13, 2010

Export Citation:

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Assignee:

NAGOYA INST TECHNOLOGY (JP)
TOSOH F TECH INC (JP)
SHIBATA NORIO (JP)
KAGAWA TAKUMI (JP)

International Classes:

C07D333/54; C07C67/343; C07C69/716; C07C69/738; C07C69/757; C07C253/30; C07C255/35; C07C323/09

Domestic Patent References:

WO1999006389A1

1999-02-11

Foreign References:

JPH03197479A	1991-08-28
JP2010120867A	2010-06-03
JP2918598B2	1999-07-12

Other References:

"89th Annual Meeting of Chemical Society of Japan in Spring (2009) Koen Yokoshu II, page 1128(Yoko no.1 G2-35) (2009)", article SHUN NORITAKE ET AL.: "Fusei Trifluoromethyl-ka Hanno no Kaihatsu Kenkyu", XP008148760
NORITAKE, S. ET AL.: "Fluorinated Johnson reagent for transfer-trifluoromethylation to carbon nucleophiles", EUR. J. ORG. CHEM., 2008, pages 3465 - 3468, XP008148749
MATSNEV, A. ET AL.: "Efficient access to extended Yagupolskii-Umemoto-type reagents: Triflic acid catalyzed cyclization of ortho- ethynylaryltrifluoromethylsulfanes", ANGEW. CHEM. INT. ED., vol. 49, 2010, pages 572 - 576, XP008148753
TETSUO SHIBATA ET AL.: "Kyudenshiteki Trifluoromethyl-ka Shiyaku no Sosei to Shin Tenkai", KAGAKU KOGYO, vol. 61, no. 4, 2010, pages 265 - 281, XP008148762
J. ORG. CHEM. USSR, vol. 20, 1984, pages 103
J. FLUORIN. CHEM., vol. 69, 1994, pages 207 - 212
See also references of EP 2460802A4