TUBULIN BINDING COMPOUNDS (COBRA)

Title:

TUBULIN BINDING COMPOUNDS (COBRA)

Document Type and Number:

WIPO Patent Application WO2000000483

Kind Code:

A9

Abstract:

Novel tubulin binding compounds having potent tubulin depolymerization activity and inhibitory activity against tubulin polymerization. The compounds are effective agents for inhibiting cellular proliferation, for example, in cancer cells. The compounds are adapted to interact favorably with a novel tubulin binding pocket, which pocket is useful for screening of anti-tubulin, anti-proliferation, and anti-cancer drugs.

Inventors:

UCKUN FATIH M
JAN SHYI-TAI M
MAO CHEN

Application Number:

PCT/US1999/014748

Publication Date:

March 30, 2000

Filing Date:

June 29, 1999

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Assignee:

WAYNE HUGHES INST (US)

International Classes:

A61K31/341; A61P35/00; A61P43/00; C07C323/41; C07D307/12; C07D307/42; C07K14/47; C07K14/82; (IPC1-7): C07D307/12; C07D307/42; C07C323/41; C07K14/47; A61K31/34; A61K31/16

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