Title:
TWO-DIMENSIONAL CULTURE METHOD HAVING CLEAR CHEMICAL COMPOSITION FOR CULTURING THREE-DIMENSIONAL INTESTINAL ORGANOID-DERIVED INTESTINAL STEM CELL AGGREGATE
Document Type and Number:
WIPO Patent Application WO/2023/153737
Kind Code:
A1
Abstract:
The present invention relates to: a method for two-dimensionally culturing an intestinal stem cell aggregate in a medium having a clear chemical composition; and a use thereof, and relates to: a method for differentiating the intestinal stem cell aggregate into 2.5-dimensional intestinal epithelial cells; and a use thereof.
Inventors:
SON MI-YOUNG (KR)
KWON OH MAN (KR)
KIM DAE SOO (KR)
KWON OH MAN (KR)
KIM DAE SOO (KR)
Application Number:
PCT/KR2023/001634
Publication Date:
August 17, 2023
Filing Date:
February 06, 2023
Export Citation:
Assignee:
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
International Classes:
C12N5/071
Domestic Patent References:
| WO2014132933A1 | 2014-09-04 | |||
| WO2022098052A1 | 2022-05-12 |
Foreign References:
| US20220033780A1 | 2022-02-03 | |||
| JP2021122208A | 2021-08-30 | |||
| KR20210119939A | 2021-10-06 | |||
| KR20190040212A | 2019-04-17 |
Other References:
KWON OHMAN, JUNG KWANG BO, LEE KYEONG-RYOON, SEUL YE, SON, LEE HANA, KIM JONG-JIN, KIM KWANGHO, LEE SEOP, SONG YOO-KYUNG, JUNG JA: "The development of a functional human small intestinal epithelium model for drug absorption ", SCIENCE ADVANCES, vol. 7, no. 23, 2 June 2021 (2021-06-02), XP055928873, DOI: 10.1126/sciadv.abh1586
Attorney, Agent or Firm:
KIM, Kyeongkyo et al. (KR)
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