Title:
ULTRA-LOW MOLECULAR WEIGHT HYALURONIC ACID AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/120521
Kind Code:
A1
Abstract:
The present invention relates to the technical field of biochemistry. Disclosed are an ultra-low molecular weight hyaluronic acid and a preparation method therefor. According to the present invention, macromolecular hyaluronic acid is used as a raw material, and is subjected to production processes such as hyaluronidase hydrolysis, heating and inactivation, activated carbon filtration, and spray drying to obtain an ultra-low molecular weight hyaluronic acid product having an average molecular weight of less than 1,200 Da. The product is a mixture of hyaluronic acid disaccharide to dodecaose. The content of hyaluronic acid disaccharide is 5-40%. The content of hyaluronic acid tetrasaccharide is 40-70%. The content of hyaluronic acid hexasaccharide is 10-30%. The content of hyaluronic acid octasaccharide is 1-15%. The content of hyaluronic acid decaose is 1-10%. The content of hyaluronic acid decaose or more is less than 6%. Compared with the common commercially available low molecular hyaluronic acid, the product has a more significant permeation, moisturizing, and repair promotion capability, and can be widely used in fields of medical products, health care products, cosmetics and the like. The method is easy to operate, mild in conditions, free of organic solvents, high in enzymolysis efficiency, and suitable for large-scale industrial production.
Inventors:
WANG YIN (CN)
CHEN JIN (CN)
CUI HUAIYAN (CN)
XU YONGGANG (CN)
TANG CHUANGEN (CN)
CHEN SONG (CN)
ZHANG HAONING (CN)
CHEN JIN (CN)
CUI HUAIYAN (CN)
XU YONGGANG (CN)
TANG CHUANGEN (CN)
CHEN SONG (CN)
ZHANG HAONING (CN)
Application Number:
PCT/CN2020/091956
Publication Date:
June 24, 2021
Filing Date:
May 23, 2020
Export Citation:
Assignee:
NANJING HANXIN PHARMACEUTICAL TECH CO LTD (CN)
International Classes:
C08B37/08; C12P19/14
Foreign References:
| CN111040048A | 2020-04-21 | |||
| CN109097421A | 2018-12-28 | |||
| CN101507733A | 2009-08-19 | |||
| US4496550A | 1985-01-29 |
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