Title:
UNNATURAL AMINO ACID AND APPLICATION THEREOF, RECOMBINANT PROTEIN CONTAINING SAME, AND RECOMBINANT PROTEIN CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2023/004687
Kind Code:
A1
Abstract:
Provided by the present invention is an unnatural amino acid, which is a compound having a structure as shown in formula (I) or an enantiomer thereof. Further provided by the present invention is an application of the unnatural amino acid. Furthermore, also provided by the present invention is a recombinant protein containing the unnatural amino acid and a protein conjugate prepared from the recombinant protein. The unnatural amino acid provided by the present invention is easy to prepare and has good safety; moreover, said amino acid does not easily lose its activity when inserted into a protein, and the binding rate to a coupling part is high. The obtained conjugate has good stability. The unnatural amino acid provided by the present invention can be applied in many fields, especially in the preparation of a recombinant protein or a recombinant protein conjugate.
Inventors:
YANG JINWEI (CN)
YE CHENGHAO (CN)
XIA GANG (CN)
HUO PENGCHAO (CN)
DING WEN (CN)
CHEN LONGFEI (CN)
JIAO LIN (CN)
HUANG HAO (CN)
HENG XIN (CN)
GONG LIYING (CN)
ZHU JINGJING (CN)
YING YUEBIN (CN)
LIANG XUEJUN (CN)
YE CHENGHAO (CN)
XIA GANG (CN)
HUO PENGCHAO (CN)
DING WEN (CN)
CHEN LONGFEI (CN)
JIAO LIN (CN)
HUANG HAO (CN)
HENG XIN (CN)
GONG LIYING (CN)
ZHU JINGJING (CN)
YING YUEBIN (CN)
LIANG XUEJUN (CN)
Application Number:
PCT/CN2021/109277
Publication Date:
February 02, 2023
Filing Date:
July 29, 2021
Export Citation:
Assignee:
NOVOCODEX BIOPHARMACEUTICALS CO LTD (CN)
International Classes:
C07C269/00; A61K38/27; A61K47/60; A61K47/68; A61P5/06; A61P35/00; C07C41/16; C07C43/178; C07C51/41; C07C53/18; C07C201/12; C07C205/43; C07C231/12; C07C235/74; C07C269/06; C07C271/22; C07D207/46; C07D233/56; C07K14/61
Foreign References:
| CN113548984A | 2021-10-26 | |||
| CN102838671A | 2012-12-26 | |||
| CN112279906A | 2021-01-29 | |||
| CN102838671B | 2014-06-11 | |||
| CN106146663A | 2016-11-23 | |||
| CN103153927B | 2017-02-15 | |||
| CN202011264982A | 2020-11-12 | |||
| CN112279906A | 2021-01-29 |
Other References:
CHRISTMAN KAREN L., BROYER REBECCA M., SCHOPF ERIC, KOLODZIEJ CHRISTOPHER M., CHEN YONG, MAYNARD HEATHER D.: "Protein Nanopatterns by Oxime Bond Formation", LANGMUIR, AMERICAN CHEMICAL SOCIETY, US, vol. 27, no. 4, 15 February 2011 (2011-02-15), US , pages 1415 - 1418, XP093030284, ISSN: 0743-7463, DOI: 10.1021/la103978x
J. AM. CHEM. SOC., vol. 131, 2009, pages 8720
LIHUA SONG ET AL., JOURNAL OF BIOLOGY, vol. 16, no. 1, 1999, pages 6 - 8
J. AM. CHEM. SOC., vol. 131, 2009, pages 8720
LIHUA SONG ET AL., JOURNAL OF BIOLOGY, vol. 16, no. 1, 1999, pages 6 - 8
Attorney, Agent or Firm:
SINO-CREATIVITY INTELLECTUAL PROPERTY LAW FIRM (CN)
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