Title:
UREIDO-THIOBUTYRIC ACID DERIVATIVES AS PPAR-AGONISTS
Document Type and Number:
WIPO Patent Application WO2000023407
Kind Code:
A3
Abstract:
Novel compounds of Formula (1) and esters, salts, and physiologically functional derivatives thereof are disclosed. Methods for preparing and using the compounds are also disclosed. Many of these compounds are selective activators of PPAR alpha. The compounds are particularly useful for treating obesity.
Inventors:
BROWN PETER JONATHAN (US)
CHAPMAN JAMES MOOD (US)
OPLINGER JEFFREY ALAN (US)
STUART LUDWIG WILLIAM (US)
WILLSON TIMOTHY MARK (US)
WU ZHENGDONG (US)
CHAPMAN JAMES MOOD (US)
OPLINGER JEFFREY ALAN (US)
STUART LUDWIG WILLIAM (US)
WILLSON TIMOTHY MARK (US)
WU ZHENGDONG (US)
Application Number:
PCT/GB1999/003420
Publication Date:
August 03, 2000
Filing Date:
October 15, 1999
Export Citation:
Assignee:
GLAXO GROUP LTD (GB)
UNIV SOUTH CAROLINA (US)
BROWN PETER JONATHAN (US)
CHAPMAN JAMES MOOD (US)
OPLINGER JEFFREY ALAN (US)
STUART LUDWIG WILLIAM (US)
WILLSON TIMOTHY MARK (US)
WU ZHENGDONG (US)
UNIV SOUTH CAROLINA (US)
BROWN PETER JONATHAN (US)
CHAPMAN JAMES MOOD (US)
OPLINGER JEFFREY ALAN (US)
STUART LUDWIG WILLIAM (US)
WILLSON TIMOTHY MARK (US)
WU ZHENGDONG (US)
International Classes:
A61K31/195; A61K31/5375; A61P1/18; C07D295/12; A61P3/04; A61P3/06; A61P3/10; A61P9/10; A61P17/06; A61P25/28; A61P29/00; A61P31/04; A61P35/00; C07C323/52; C07C323/63; C07D295/135; (IPC1-7): C07C323/62; A61K31/17; C07D295/135
Domestic Patent References:
| WO1995018533A1 | 1995-07-13 | |||
| WO1998043081A1 | 1998-10-01 |
Other References:
P.J.BROWN ET AL.: "A Ureido-Thiobutyric Acid (GW9578)", J. MED. CHEM., vol. 42, no. 19, 9 April 1999 (1999-04-09), pages 3785 - 3788, XP002128791
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