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Title:
USE OF ANTICONVULSANT DERIVATIVES FOR TREATING CLUSTER HEADACHES
Document Type and Number:
WIPO Patent Application WO2000042996
Kind Code:
A3
Abstract:
The use of anticonvulsant derivatives of formula (I) treating cluster headaches is disclosed. Wherein X is CH2 or oxygen; R1 is hydrogen of C1-C4 alkyl; and R2, R3, R4 and R5 are independently hydrogen or C1-C3 alkyl and, when X is CH2, R4 and R5 may be alkene groups joined to form a benzene ring and, when X is oxygen, R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of the following formula (II): wherein R6 and R7 are the same or different and are hydrogen, C1-C3 alkyl or R6 and R7 together with the carbon to which they are attached are joined to form a cyclopentyl or cyclohexyl ring.

Inventors:
CARRAZANA ENRIQUE (US)
WHEELER STEVE D (US)
Application Number:
PCT/US2000/000919
Publication Date:
December 07, 2000
Filing Date:
January 13, 2000
Export Citation:
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Assignee:
ORTHO MCNEIL PHARM INC (US)
CARRAZANA ENRIQUE (US)
WHEELER STEVE D (US)
International Classes:
C07H9/04; A61K31/00; A61K31/255; A61K31/35; A61K31/7028; A61K31/7048; A61P25/00; A61P25/06; (IPC1-7): A61K31/255; A61K31/35; A61K31/7048; A61P25/00; A61P25/06
Domestic Patent References:
WO1997013510A11997-04-17
WO1998015270A11998-04-16
Foreign References:
US4513006A1985-04-23
Other References:
WHEELER, STEVE D. (1) ET AL: "Topiramate -treated cluster headache.", NEUROLOGY, (JULY 13, 1999) VOL. 53, NO. 1, PP. 234-236., XP000921301
"The Merck Manual", 1987, MERCK SHARP & DOHME RESEARCH LABORATORIES, RAHWAY, N.J., XP002144176
KUZNIECKY R ET AL: "Topiramate increases cerebral GABA in healthy humans.", NEUROLOGY, (1998 AUG) 51 (2) 627-9., XP000923467
HERING R ET AL: "Sodium valproate in the treatment of cluster headache: an open clinical trial.", CEPHALALGIA, (1989 SEP) 9 (3) 195-8., XP000923459
WHEELER S.D.: "Significance of migrainous features in cluster headache: Divalproex responsiveness.", HEADACHE, (1998) 38/7 (547-551)., XP000923465
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