Title:
USE OF ANTICONVULSANT DERIVATIVES FOR TREATING TRANSFORMED MIGRAINE
Document Type and Number:
WIPO Patent Application WO2000042995
Kind Code:
A3
Abstract:
The use of anticonvulsant derivatives of formula (I) for treating transformed migraine is disclosed. Wherein X is CH2 or oxygen; R1 is hydrogen or C1-C4 alkyl; and R2, R3, R4 and R5 are independently hydrogen or C1-C3 alkyl and, when X is CH2, R4 and R5 may be alkene groups joined to form a benzene ring and, when X is oxygen, R2 and R3 and/or R4 and R5 together may be a methylenedioxy group of the following formula (II): wherein R6 and R7 are the same or different and are hydrogen, C1-C3 alkyl or R6 and R7 together with the carbon to which they are attached are joined to form a cyclopentyl or cyclohexyl ring.
Inventors:
POTTER DOREEN L
Application Number:
PCT/US2000/001382
Publication Date:
November 30, 2000
Filing Date:
January 20, 2000
Export Citation:
Assignee:
ORTHO MCNEIL PHARM INC (US)
International Classes:
A61K31/255; A61K31/35; (IPC1-7): A61K31/255; A61K31/35; A61K31/7048; A61P25/06
Domestic Patent References:
| WO1997013510A1 | 1997-04-17 | |||
| WO1998015270A1 | 1998-04-16 |
Foreign References:
| US4513006A | 1985-04-23 |
Other References:
STOREY, JAMES R. (1) ET AL: "Potential role of topiramate (TPM) in the treatment of intractable daily headache: A retrospective pilot study.", NEUROLOGY, (APRIL 12, 1999) VOL. 52, NO. 6 SUPPL. 2, PP. A211. MEETING INFO.: 51ST ANNUAL MEETING OF THE AMERICAN ACADEMY OF NEUROLOGY TORONTO, ONTARIO, CANADA APRIL 17-24, 1999 AMERICAN ACADEMY OF NEUROLOGY., XP000921300
SHUAIB A (REPRINT) ET AL: "Topiramate in migraine prophylaxis: a pilot study.", CEPHALALGIA, (MAY 1999) VOL. 19, NO. 4, PP. 379-380. PUBLISHER: SCANDINAVIAN UNIVERSITY PRESS, PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY. ISSN: 0333-1024., UNIV ALBERTA, EDMONTON, AB T6G 2M7, CANADA, XP000923377
KUZNIECKY R ET AL: "Topiramate increases cerebral GABA in healthy humans.", NEUROLOGY, (1998 AUG) 51 (2) 627-9., XP000923467
ROTHROCK, J. F. (1) ET AL: "A differential response to treatment with divalproex sodium in patients with intractable headache.", CEPHALALGIA, (1994) VOL. 14, NO. 3, PP. 241-244., XP000924812
TRAN, BIHN N. (1) ET AL: "Can valproate prevent migraine headaches.", JOURNAL OF PHARMACY TECHNOLOGY, (1997) VOL. 13, NO. 4, PP. 163-168., XP000925386
SHUAIB A (REPRINT) ET AL: "Topiramate in migraine prophylaxis: a pilot study.", CEPHALALGIA, (MAY 1999) VOL. 19, NO. 4, PP. 379-380. PUBLISHER: SCANDINAVIAN UNIVERSITY PRESS, PO BOX 2959 TOYEN, JOURNAL DIVISION CUSTOMER SERVICE, N-0608 OSLO, NORWAY. ISSN: 0333-1024., UNIV ALBERTA, EDMONTON, AB T6G 2M7, CANADA, XP000923377
KUZNIECKY R ET AL: "Topiramate increases cerebral GABA in healthy humans.", NEUROLOGY, (1998 AUG) 51 (2) 627-9., XP000923467
ROTHROCK, J. F. (1) ET AL: "A differential response to treatment with divalproex sodium in patients with intractable headache.", CEPHALALGIA, (1994) VOL. 14, NO. 3, PP. 241-244., XP000924812
TRAN, BIHN N. (1) ET AL: "Can valproate prevent migraine headaches.", JOURNAL OF PHARMACY TECHNOLOGY, (1997) VOL. 13, NO. 4, PP. 163-168., XP000925386
Download PDF:
Previous Patent: INHIBITION OF BACTERIAL DISSEMINATION
Next Patent: USE OF ANTICONVULSANT DERIVATIVES FOR TREATING CLUSTER HEADACHES
Next Patent: USE OF ANTICONVULSANT DERIVATIVES FOR TREATING CLUSTER HEADACHES