Title:
USE OF BIS-IMINOBIOTIN COMPOUND FOR DRUG DELIVERY PURPOSES
Document Type and Number:
WIPO Patent Application WO/2019/189867
Kind Code:
A1
Abstract:
The technical problem of the present invention is to provide a bis-iminobiotin compound which has a structure that enables the easy bonding of a bis-iminobiotin moiety to a drug or a fluorescent compound and is useful for the delivery of a drug to a streptavidin-labeled substance. The bis-iminobiotin compound that can solve the technical problem of the present invention is represented by general formula 9. (In the formula, A, D and E independently represent a spacer capable of bonding two bicyclo rings to each other, wherein E represents a structure that may be branched, each of A, D and E may have a substituent, and A, D and E may together form a cyclic structure; J represents a functional group for achieving a click reaction; G represents a spacer capable of bonding E to J; and R represents a hydrogen atom, an acetyl group, a benzyl group, a trifluoroacetyl group or a Boc group.)
Inventors:
SUZUKI TSUNEJI (JP)
MANO KOSUKE (JP)
TOTANI YOSHIYUKI (JP)
SHIMIZU YOHEI (JP)
SUGIYAMA AKIRA (JP)
TSUKAGOSHI MASANOBU (JP)
MANO KOSUKE (JP)
TOTANI YOSHIYUKI (JP)
SHIMIZU YOHEI (JP)
SUGIYAMA AKIRA (JP)
TSUKAGOSHI MASANOBU (JP)
Application Number:
PCT/JP2019/014284
Publication Date:
October 03, 2019
Filing Date:
March 29, 2019
Export Citation:
Assignee:
MITSUI CHEMICALS INC (JP)
UNIV TOKYO (JP)
SAVID THERAPEUTICS INC (JP)
UNIV TOKYO (JP)
SAVID THERAPEUTICS INC (JP)
International Classes:
A61K47/54; A61K45/00; C07D519/00; G01N33/53
Domestic Patent References:
| WO2015125820A1 | 2015-08-27 | |||
| WO2017132298A1 | 2017-08-03 | |||
| WO2015125820A1 | 2015-08-27 |
Other References:
SIBBERSEN, CHRISTIAN ET AL.: "A cleavable azide resin for direct click chemistry mediated enrichment of alkyne-labeled proteins", CHEMICAL COMMUNICATIONS, vol. 50, no. 81, 21 August 2014 (2014-08-21) - 18 October 2014 (2014-10-18), pages 12098 - 12100, XP055639157
SZYCHOWSKI, JANEK ET AL.: "Cleavable Biotin Probes for Labeling of Biomolecules via the Azide-Alkyne Cycloaddition", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 132, no. 51, 29 November 2010 (2010-11-29), pages 18351 - 18360, XP055029467, doi:10.1021/ja1083909
GOLAS, PATRICIA L. ET AL.: "Marrying click chemistry with polymerization: expanding the scope of polymeric materials", CHEMICAL SOCIETY REVIEWS, vol. 39, no. 4, 2010, pages 1338 - 1354, XP055167091, doi:10.1039/B901978M
CAS, no. 1255942-06-3
See also references of EP 3777893A4
SZYCHOWSKI, JANEK ET AL.: "Cleavable Biotin Probes for Labeling of Biomolecules via the Azide-Alkyne Cycloaddition", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 132, no. 51, 29 November 2010 (2010-11-29), pages 18351 - 18360, XP055029467, doi:10.1021/ja1083909
GOLAS, PATRICIA L. ET AL.: "Marrying click chemistry with polymerization: expanding the scope of polymeric materials", CHEMICAL SOCIETY REVIEWS, vol. 39, no. 4, 2010, pages 1338 - 1354, XP055167091, doi:10.1039/B901978M
CAS, no. 1255942-06-3
See also references of EP 3777893A4
Attorney, Agent or Firm:
MIYAZAKI Teruo et al. (JP)
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