Title:
USE OF FLUOROPYRIDOXAL IN PREPARING MEDICAMENT AGAINST CANCER
Document Type and Number:
WIPO Patent Application WO/2024/060834
Kind Code:
A1
Abstract:
The present invention relates to the technical field of biopharmaceuticals, and particularly, to use of fluoropyridoxal in preparing a medicament against a cancer, comprising: use in preparing a medicament for preventing and/or relieving and/or treating a cancer. The cancer is ovarian cancer. The medicament for preventing and/or relieving and/or treating the cancer comprises fluoropyridoxal and a pharmaceutically acceptable carrier. The dosage form of the medicament for preventing and/or relieving and/or treating the cancer is a tablet, a granule, a capsule, a suspension, a syrup, an emulsion, or an injection. Fluoropyridoxal induces the senescence-like death, cycle retardation, and cell apoptosis in cancer cells. Fluoropyridoxal works by inducing the apoptosis of cancer cells. According to the present invention, fluoropyridoxal can effectively inhibit the proliferation and growth of human ovarian cancer cell lines SKOV3, OVCAR3, 3AO, and ES-2. Fluoropyridoxal of the present invention can be used as an effective therapy for treating ovarian cancer.
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Inventors:
LINGHU HUA (CN)
LI RUONAN (CN)
LI RUONAN (CN)
Application Number:
PCT/CN2023/109823
Publication Date:
March 28, 2024
Filing Date:
July 28, 2023
Export Citation:
Assignee:
FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIV (CN)
International Classes:
A61K31/44; A61P35/00
Foreign References:
| CN115531380A | 2022-12-30 | |||
| CN112691103A | 2021-04-23 | |||
| CN106727620A | 2017-05-31 | |||
| US20090215727A1 | 2009-08-27 |
Other References:
J. KOLLONITSCH, S. MARBURG, LEROY M. PERKINS: "Fluorodehydroxylation, a Novel Method for Synthesis of Fluoroamines and Fluoroamino Acids", THE JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, vol. 44, no. 5, 1 March 1979 (1979-03-01), pages 771 - 777, XP008143751, ISSN: 0022-3263, DOI: 10.1021/jo01319a023
Attorney, Agent or Firm:
BEIJING FINELAND IP FIRM (CN)
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