Title:
USE OF INTESTINAL BACTERIA IN PREPARATION OF DRUG FOR PROMOTING TCR γδ+T CELL PROLIFERATION
Document Type and Number:
WIPO Patent Application WO/2020/223988
Kind Code:
A1
Abstract:
Provided are the use of one or more intestinal bacteria selected from Alistipes shahii, Eubacterium ramulus, Eubacterium siraeum, Prevotella ruminicola, Ruminococcus lactaris, Anaerofustis stercorihominis, Clostridium nexile, Sanguibacteroides justesenii, Dorea formicigenerans or Bifidobacterium saeculare in the preparation of drugs for promoting the accumulation of CD8-positive killer T lymphocytes and/or promoting TCRγδ+T cell proliferation and resisting tumors; and compositions, foods, health products and food additives containing the drugs of the one or more intestinal bacteria for promoting the accumulation of CD8-positive killer T lymphocytes and/or promoting TCRγδ+T cell proliferation and resisting tumors.
Inventors:
CAI QINGQING (CN)
Application Number:
PCT/CN2019/086598
Publication Date:
November 12, 2020
Filing Date:
May 13, 2019
Export Citation:
Assignee:
REVAISSANT SHENZHEN BIOSCIENCES CO LTD (CN)
International Classes:
A61K35/745
Foreign References:
| CN106170557A | 2016-11-30 |
Other References:
TANOUE TAKESHI ET AL.: "A defined commensal consortium elicits CD 8 T cells and anti- cancer immunity", NATURE, vol. 565, no. 7741, 31 January 2019 (2019-01-31), pages 600 - 605, XP036694915, DOI: 10.1038/s41586-019-0878-z
LI ZHIYUAN ET AL.: "Small Intestinal Intraepithelial Lymphocytes Expressing CD 8 and T Cell Receptor gammadelta Are Involved in Bacterial Clearance during Salmonella enterica Serovar Typhimurium Infection", INFECTION AND IMMUNITY, vol. 80, no. 2, 29 February 2012 (2012-02-29), pages 565 - 574, XP055752240, DOI: 10.1128/IAI.05078-11
YANG YUNBEN ET AL.: "gammadelta T Cells: Crosstalk Between Microbiota, Chronic inflammation, and Colorectal Cancer", FRONTIERS IN IMMUNOLOGY, vol. 9, 26 June 2018 (2018-06-26), pages 1 - 7, XP055752243, DOI: 10.3389/fimmu.2018.01483
SCIENCE, 2013
See also references of EP 3967317A4
LI ZHIYUAN ET AL.: "Small Intestinal Intraepithelial Lymphocytes Expressing CD 8 and T Cell Receptor gammadelta Are Involved in Bacterial Clearance during Salmonella enterica Serovar Typhimurium Infection", INFECTION AND IMMUNITY, vol. 80, no. 2, 29 February 2012 (2012-02-29), pages 565 - 574, XP055752240, DOI: 10.1128/IAI.05078-11
YANG YUNBEN ET AL.: "gammadelta T Cells: Crosstalk Between Microbiota, Chronic inflammation, and Colorectal Cancer", FRONTIERS IN IMMUNOLOGY, vol. 9, 26 June 2018 (2018-06-26), pages 1 - 7, XP055752243, DOI: 10.3389/fimmu.2018.01483
SCIENCE, 2013
See also references of EP 3967317A4
Attorney, Agent or Firm:
GUANGZHOU SINO PATENT & TRADEMARK AGENT CO., LTD. (CN)
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